{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:48:43Z","timestamp":1775101723934,"version":"3.50.1"},"reference-count":161,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007406","name":"Fundaci\u00f3n BBVA","doi-asserted-by":"publisher","award":["865157"],"award-info":[{"award-number":["865157"]}],"id":[{"id":"10.13039\/100007406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Axons share a close relationship with Schwann cells, their glial partners in peripheral nerves. An intricate axo\u2010glia network of signals and bioactive molecules regulates the major aspects of nerve development and normal functioning of the peripheral nervous system. Disruptions to these complex axo\u2010glial interactions can have serious neurological consequences, as typically seen in injured nerves. Recent studies in inherited neuropathies have demonstrated that damage to one of the partners in this symbiotic unit ultimately leads to impairment of the other partner, emphasizing the bidirectional influence of axon to glia and glia to axon signaling in these diseases. After physical trauma to nerves, dramatic alterations in the architecture and signaling environment of peripheral nerves take place. Here, axons and Schwann cells respond adaptively to these perturbations and change the nature of their reciprocal interactions, thereby driving the remodeling and regeneration of peripheral nerves. In this review, we focus on the nature and importance of axon\u2010glia interactions in injured nerves, both for the reshaping and repair of nerves after trauma, and in driving pathology in inherited peripheral neuropathies.<\/jats:p>","DOI":"10.1002\/dneu.22771","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T12:17:07Z","timestamp":1594037827000},"page":"490-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Axo\u2010glial interaction in the injured PNS"],"prefix":"10.1002","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5919-1652","authenticated-orcid":false,"given":"Ruth M.","family":"Stassart","sequence":"first","affiliation":[{"name":"Department of Neuropathology University Clinic Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Woodhoo","sequence":"additional","affiliation":[{"name":"Nerve Disorders Laboratory Center for Cooperative Research in Biosciences (CIC bioGUNE) Basque Research and Technology Alliance (BRTA) Bizkaia Spain"},{"name":"IKERBASQUE Basque Foundation for Science Bilbao Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/265073a0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.05.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.021"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4594\u201005.2006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1055"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1447\u201008.2008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bies.201800075","article-title":"The LKB1\u2010AMPK and mTORC1 metabolic signaling networks in schwann cells control axon integrity and myelination: Assembling and upholding nerves by metabolic signaling in Schwann cells","volume":"41","author":"Beirowski B.","year":"2019","journal-title":"BioEssays"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-6-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3809"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy420"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3481\u201016.2017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1997.0654"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-07311-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00038"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606349"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2005.03635.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:27:3:277"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3176"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710566114"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.05.007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072\u2010197911000\u201000002"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.10.024"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17\u201005\u201001642.1997"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.01.048"},{"key":"e_1_2_9_26_1","first-page":"1013","article-title":"Schwann cell development, maturation and regeneration: A focus on classic and emerging intracellular signaling pathways","volume":"7","author":"Castelnovo L. F.","year":"2017","journal-title":"Neural Regeneration Research"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.489"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.021"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2016.04.005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2255\u201017.2017"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094337"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490310406"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1788"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010020\u20100269\u20103"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3680"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122005"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.022"},{"key":"e_1_2_9_38_1","first-page":"742","article-title":"Histologic measurements and fine structure of biopsied sural nerve: Normal, and in peroneal muscular atrophy, hypertrophic neuropathy, and congenital sensory neuropathy","volume":"41","author":"Dyck P. J.","year":"1966","journal-title":"Mayo Clinic Proceedings"},{"key":"e_1_2_9_39_1","first-page":"400","article-title":"Segmental demyelination secondary to axonal degeneration in uremic neuropathy","volume":"46","author":"Dyck P. J.","year":"1971","journal-title":"Mayo Clinic Proceedings"},{"key":"e_1_2_9_40_1","first-page":"225","article-title":"Spatial pattern of nerve fiber abnormality indicative of pathologic mechanism","volume":"117","author":"Dyck P. J.","year":"1984","journal-title":"American Journal of Pathology"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090611"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.07.021"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6810\u201010.2011"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.10.012"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20657"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09385-6"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.151704"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3664"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0201\u201018.2018"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201205025"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23705"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt148"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2568\u201010.2011"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15\u201005\u201003886.1995"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww251"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1258366"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.12.023"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.09.027"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22627"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201503019"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1453\u201017.2017"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3171\/FOC.2009.26.2.E3"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11\u201007\u201002157.1991"},{"key":"e_1_2_9_64_1","first-page":"130","article-title":"Demyelination in experimental beta, beta\u2019\u2010iminodipropionitrile and hexacarbon neuropathies. Evidence for an axonal influence","volume":"45","author":"Griffin J. W.","year":"1981","journal-title":"Laboratory Investigation"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq269"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3766\u201004.2005"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102990.1986.tb00679.x"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.5.1461"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050712"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu257"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600309"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.022"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10108"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0262"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.12.001"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1620\u201006.2006"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a070225"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08\u2010106666"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5207\u201014.2015"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529\u20108027.2011.00360.x"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.10.004"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22957"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23532"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20761"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270874"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00033"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.09.005"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.07.009"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2013.04.004"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.06.002"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056484"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4537\u201010.2011"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1229"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81173-3"},{"key":"e_1_2_9_95_1","volume-title":"Atlas of peripheral nerve pathology","author":"King R. H. M.","year":"1999"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22638"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.11.033"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909794107"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090694"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.08.003"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0278\u201013.2013"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1924\u201015.2015"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17\u201021\u201008293.1997"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2466\u201012.2012"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2085\u201017.2017"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010015\u20100314\u20103"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22558"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.11.002"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010018\u20100001\u20108"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.06.002"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14\u201011\u201007180.1994"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.12.014"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.12.006"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095862"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201606052"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000056993.28149.BF"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.031"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn905"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.09.018"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3319\u201012.2013"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500080061010"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201001488\u20102"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws299"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00093"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.1995.tb01063.x"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490100019001"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068613"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056282"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2007\u201014.2014"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5225\u201011.2012"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687785"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-07-02833.2003"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy411"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.227"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20751"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.151409"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165\u20105728(00)00343\u2010X"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(94)90492\u20108"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2005.03564.x"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01097197"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3281"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00467"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.04.002"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.170316"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098\u20101136(200012)32:3<234:AID\u2010GLIA40>3.0.CO;2\u20103"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.07.003"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266\u20107681(98)80006\u20105"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.10.015"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20533"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12219"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.05.060"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21255"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.012"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749\u20108104\u20107\u201019"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstl.1850.0021"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10300"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0334"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.11.007"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2323"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.018184"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2008.01.017"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2018.12.001"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.22771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dneu.22771","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T09:45:01Z","timestamp":1752918301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":161,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/dneu.22771"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22771","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]},"assertion":[{"value":"2020-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}