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The purpose of our study was to further investigate the effects of Wallerian degeneration (WD) after rat sciatic nerve injury and to screen for critical long noncoding RNAs (lncRNAs) in WD. We found H19 to be essential for nerve degeneration and regeneration and to be highly expressed in the sciatic nerves of rats with WD. lncRNA H19 potentially impaired the recovery of sciatic nerve function in rats. H19 was mainly localized in the cytoplasm of Schwann cells (SCs) and promoted their migration. H19 promoted the apoptosis of dorsal root ganglion (DRG) neurons and slowed the growth of DRG axons. The lncRNA H19 may play a role in WD through the Wnt\/\u03b2\u2010catenin signaling pathway and is coexpressed with a variety of crucial mRNAs during WD. These data provide further insight into the molecular mechanisms of WD.<\/jats:p>","DOI":"10.1002\/dneu.22861","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T10:01:32Z","timestamp":1637834492000},"page":"98-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of lncRNA H19 on nerve degeneration and regeneration after sciatic nerve injury in rats"],"prefix":"10.1002","volume":"82","author":[{"given":"Yuting","family":"Li","sequence":"first","affiliation":[{"name":"School of Life Sciences, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co\u2010innovation Center of Neuroregeneration Nantong University  Nantong P. R. 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