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Here, we further highlight the significance of this gene family in visual development by identifying a role for Ten\u2010m4 during the formation of the ipsilateral projection in the mouse. Ten\u2010m4 was found to be expressed in the retina, dorsal lateral geniculate nucleus (dLGN), superior colliculus (SC), and primary visual cortex (V1) during development. Anterograde and retrograde tracing experiments in Ten\u2010m4 knockout (KO) mice revealed a specific increase in ipsilateral retinal ganglion cells projecting to dLGN and SC. This increase was most prominent in regions corresponding to temporal retina. Consistent with this, EphB1 expression in the retina around the time of decussation was enhanced in this temporal region for KO mice, suggesting that the increased size of the ipsilateral population arises due to an increased number of retinal ganglion cells remaining ipsilaterally at the optic chiasm due to EphB1\u2010mediated repulsion. The ectopic ipsilaterally targeted retinal ganglion cell projection observed in Ten\u2010m4 KOs was associated with changes in response to ethologically relevant visual stimuli. Together, these data demonstrate a requirement for Ten\u2010m4 in the establishment of ipsilateral projections from the retina, which likely acts in combination with other Ten\u2010m members (Ten\u2010m2 and Ten\u2010m3) to promote the formation of functional binocular circuits.<\/jats:p>","DOI":"10.1002\/dneu.22912","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T12:55:15Z","timestamp":1682340915000},"page":"104-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ten\u2010m4 plays a unique role in the establishment of binocular visual circuits"],"prefix":"10.1002","volume":"83","author":[{"given":"Timothy R.","family":"Young","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Black","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannan","family":"Mansuri","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Oohashi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Max\u2010Planck Institute for Biochemistry  Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Max\u2010Planck Institute for Biochemistry  Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atomu","family":"Sawatari","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-4933","authenticated-orcid":false,"given":"Catherine A.","family":"Leamey","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.09.045"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.05.035"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.08.008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25463"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.00022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63377"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.504779"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2013.05.011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.02.048"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0394\u201011.2011"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00158"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.08.010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2012.00009"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.12.014"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","unstructured":"Deng J. 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