{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:14Z","timestamp":1786977554735,"version":"build-2736575974"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hypoxia, or low oxygen levels, is linked to several pathological disorders, including retinopathies. Retina being a metabolically active tissue, low oxygen levels resulted in retinal degradation. The developmental perspective of hypobaric hypoxia (HBH)\u2010induced eye development remains elusive.\n                    <jats:italic>Drosophila<\/jats:italic>\n                    is used as our model organism to investigate the impact of HBH on eye development and alpha\u2010tocopherol as a potential inhibitor. To induce the hypoxic condition, we exposed the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    to hypobaric pressure (120\u00a0mbar). Hypoxia induces eye defects in different developmental stages of\n                    <jats:italic>Drosophila<\/jats:italic>\n                    as revealed by histological staining. Biochemical estimation disclosed the presence of reactive oxygen species (ROS) during hypoxia, which led to cellular injury and DNA damage. Quantitative PCR reveals the upregulation of\n                    <jats:italic>Puf<\/jats:italic>\n                    ,\n                    <jats:italic>Wge<\/jats:italic>\n                    , and\n                    <jats:italic>Twr<\/jats:italic>\n                    genes and the downregulation of\n                    <jats:italic>Rh1<\/jats:italic>\n                    and\n                    <jats:italic>Rh6<\/jats:italic>\n                    involved in eye development. All these defects are brought back to normal levels after treatment with alpha\u2010tocopherol. This research provides a foundation for understanding ocular developmental problems caused by oxygen deprivation and alpha\u2010tocopherol as a crucial therapeutic approach to the treatment of HBH.\n                  <\/jats:p>","DOI":"10.1002\/dneu.22963","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:53:34Z","timestamp":1741712014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Mechanism Behind the Therapeutic Role of Alpha\u2010Tocopherol in Mitigating Hypobaric Hypoxia\u2013Induced Eye Defect in\n                    <i>Drosophila melanogaster<\/i>"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4013-5367","authenticated-orcid":false,"given":"Seekha","family":"Naik","sequence":"first","affiliation":[{"name":"Neural Developmental Biology Lab, Department of Life Science NIT Rourkela  Rourkela Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smruti Sudha","family":"Biswal","sequence":"additional","affiliation":[{"name":"Neural Developmental Biology Lab, Department of Life Science NIT Rourkela  Rourkela Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9735-7027","authenticated-orcid":false,"given":"Monalisa","family":"Mishra","sequence":"additional","affiliation":[{"name":"Neural Developmental Biology Lab, Department of Life Science NIT Rourkela  Rourkela Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010089"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marenvres.2021.105389"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-68164-1_22"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.09.144"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9756-5_13"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.1.35"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/152702901750067882"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011532"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-022-09962-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327595"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-020-00658-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.4.607"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00156-4"},{"issue":"2","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/cbf.1344","article-title":"Intermittent Hypobaric Hypoxia\u2010Induced Oxidative Stress in Rat Erythrocytes: Protective Effects of Vitamin E, Vitamin C, and Carnitine","volume":"25","author":"Devi S. A.","year":"2007","journal-title":"Cell Biochemistry and Function: Cellular Biochemistry and Its Modulation by Active Agents or Disease"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9756-5_8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00520.2004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1226044"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83884"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/25158414241280187"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-62226-8_18"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmpp.2003.11.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/RES.0000000000000110"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.58419"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009551"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00581-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2020.110505"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094642"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00976"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9756-5_4"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218320"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022237"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-016-0186-5"},{"key":"e_1_2_10_35_1","volume-title":"The Genetic and Developmental Analysis of Female Sterile Loci Associated With the Antennapedia Complex in Drosophila Melanogaster (Maternal Effect, Pattern Formation)","author":"Lambert L. A.","year":"1985"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.096941"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)02010-1"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","unstructured":"Milledge J.2020.Hypobaria: High Altitude Aviation Physiology and Medicine. Chap. 34 Cotes' Lung Function615\u2013637.","DOI":"10.1002\/9781118597309.ch32"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2004.03.007"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-017-3971-y"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7883-0_14"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9080363"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2021.1914335"},{"issue":"2","key":"e_1_2_10_44_1","first-page":"447","article-title":"Mitonuclear Interactions Mediate Transcriptional Responses to Hypoxia in Drosophila","volume":"34","author":"Mossman J. A.","year":"2016","journal-title":"Molecular Biology and Evolution"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2023.134741"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2015.11.032"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119758"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2019.1634171"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3164734"},{"issue":"2","key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1183\/18106838\/breathe.4.2.122","article-title":"Lessons From High\u2010Altitude Physiology","volume":"4","author":"Nussbaumer\u2010Ochsner Y.","year":"2007","journal-title":"Breathe"},{"key":"e_1_2_10_51_1","volume-title":"Ultraviolet Radiation: An Authoritative Scientific Review of Environmental and Health Effects of UV, With Reference to Global Ozone Layer Depletion","author":"Organization W. H.","year":"1994"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12354"},{"issue":"17","key":"e_1_2_10_53_1","first-page":"e2545","article-title":"Detection of Reactive Oxygen Species (ROS) in Cyanobacteria Using the Oxidant\u2010Sensing Probe 2', 7'\u2010Dichlorodihydrofluorescein Diacetate (DCFH\u2010DA)","volume":"7","author":"Pathak J.","year":"2017","journal-title":"Bio\u2010Protocol"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-05357-x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.06.007"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9756-5_7"},{"key":"e_1_2_10_58_1","volume-title":"Comparative Effects of Emodin on Biological Activities of MCF\u20107 and MDA\u2010231 Cell Lines","author":"Sakall\u0131 E.","year":"2010"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2023.108361"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.03.034"},{"key":"e_1_2_10_61_1","volume-title":"Atmospheric Chemistry and Physics: From Air Pollution to Climate Change","author":"Seinfeld J. H.","year":"2016"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology8010006"},{"issue":"4","key":"e_1_2_10_63_1","first-page":"356","article-title":"Molecular Genetics of Retinal Degeneration: A Drosophila Perspective","volume":"5","author":"Shieh B.\u2010H.","year":"2011","journal-title":"Flyer"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00947"},{"issue":"10","key":"e_1_2_10_65_1","article-title":"A Review of Contact Lens\u2010Related Risk Factors and Complications","volume":"14","author":"Waghmare S. V.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1149664"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(83)90113-1"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyac041"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101588"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20102"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00485.2010"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90402-5"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80425-8"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-091212-153439"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T03:29:20Z","timestamp":1745897360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":73,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/dneu.22963"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22963","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"2024-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22963"}}