{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:59:19Z","timestamp":1773014359973,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Major depressive disorder (MDD) is a common neuropsychiatric disorder with persistent low mood, feelings of weakness, and a lack of interestin daily tasks. Histamine N\u2010methyltransferase (HNMT) protein is involved in the inactivation process of\u00a0histamine in human physiology. Here, we aimed to assess the role of HNMT in the pathophysiology and development of MDD. This case\u2013control study included 56 MDD patients and 32 healthy controls (HCs) by matching age, sex, body mass index (BMI), and other sociodemographic characteristics. A clinical psychiatrist assessed the MDD patients and HCs according to\u00a0the DSM\u20105 criteria. We used the Ham\u2010D scale in evaluating the severity of depressive symptoms. We used ELISA kits to estimate serum HNMT levels. We observed elevated serum HNMT concentration in MDD patients (29.25 \u00b1 5.34 pg\/ml) compared with HCs (23.13 \u00b1 2.10 pg\/ml). Serum HNMT levels and Ham\u2010D scores are positively correlated with each other in MDD patients (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.632,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Also, the receiver operating characteristic curve analysis illustrated a significant diagnostic value for HNMT with the area under the curve (AUC = 0.916) at\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001. The promising findings from this study anticipate that the elevated serum levels of HNMT may be associated with the pathophysiology and mechanism of MDD. We recommend further interventional studies to produce more precise and accurate results on this biomarker in depression.\n                  <\/jats:p>","DOI":"10.1002\/dneu.22967","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:31:21Z","timestamp":1746174681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Serum Histamine N\u2010Methyltransferase Levels Are Associated With the Pathophysiology of Major Depressive Disorder: A Case\u2013Control Study"],"prefix":"10.1002","volume":"85","author":[{"given":"Mariya","family":"Akter","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Asia Pacific  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dibbo Protim","family":"Ghosh","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toha","family":"Tasnem","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanvir","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences North South University  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Aminul","family":"Haque","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Siddiqul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Southeast University  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-3144","authenticated-orcid":false,"given":"Md. Rabiul","family":"Islam","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0305734"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010023\u201005354\u2010y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2020.102164"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125320916655"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991\u2010014\u20100034\u2010y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.002"},{"key":"e_1_2_10_9_1","volume-title":"StatPearls","author":"Chand S. P.","year":"2023"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03159928"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010019\u20101117\u2010x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312120974169"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6081"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2017.01.025"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104\u2010020\u201004952\u20103"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11101408"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010018\u20101685\u2010z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez E. M. T.\u017bo\u0142ek P. G.Hern\u00e1ndez Perez R.Miranda Ruvalcaba M. I.Nicol\u00e1s\u2010V\u00e1zquez andM.Hern\u00e1ndez\u2010Rodr\u00edguez.2023.Drug Repurposing to Inhibit Histamine N\u2010Methyl Transferase Molecules (Basel Switzerland).28 no.2:576.https:\/\/doi.org\/10.3390\/molecules28020576.","DOI":"10.3390\/molecules28020576"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2004.03540.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2014.02.015"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1175"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010023\u201005463\u20108"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.3868"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109065"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.825591"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264404"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605231166222"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010024\u201005911\u2010z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2016_125"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.09.008"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2010.10.010"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12844"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/2632010x231220841"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2019.05.002"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.UT17042BR1C"},{"key":"e_1_2_10_36_1","unstructured":"World Health Organization.2023. \u201cDepressive Disorder (Depression) \u201d.. WHO.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/depression."},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201967119"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030737"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dneu.22967","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:47:03Z","timestamp":1773010023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/dneu.22967"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22967","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,1]]},"assertion":[{"value":"2025-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22967"}}