{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:47:37Z","timestamp":1784000857732,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Retinal ganglion cells (RGCs) exhibit remarkable diversity owing to their expression of developmentally expressed transcription factors. Many transcription factors are expressed in unique RGC populations, but their roles within these populations remain undiscovered. The transcription factor Islet\u20102 (\n                    <jats:italic>Isl2<\/jats:italic>\n                    ) is expressed in approximately 30%\u201340% of contralateral projecting RGCs. Previous work by others found increased ipsilateral innervation of the dorsal lateral geniculate nucleus (dLGN) in\n                    <jats:italic>Isl2<\/jats:italic>\n                    mutant mice, implicating\n                    <jats:italic>Isl2<\/jats:italic>\n                    in promoting a contralateral RGC axon trajectory. Since\n                    <jats:italic>Isl2<\/jats:italic>\n                    mutant mice suffer early neonatal lethality, the role of\n                    <jats:italic>Isl2<\/jats:italic>\n                    in RGC specification has not been fully explored. To test the role of\n                    <jats:italic>Isl2<\/jats:italic>\n                    in RGC development, two lines of retina\u2010specific\n                    <jats:italic>Isl2<\/jats:italic>\n                    mutant mice were generated. Contrary to the findings in\n                    <jats:italic>Isl2<\/jats:italic>\n                    null mice,\n                    <jats:italic>Isl2<\/jats:italic>\n                    retinal deletion does not lead to early postnatal lethality or increased ipsilateral projections to the dLGN. Instead, there is a significant reduction in the size of the dLGN and a mild reduction in the size of the ipsilateral projection to the dLGN. Retinal\n                    <jats:italic>Isl2<\/jats:italic>\n                    mutants also exhibit diminished expression of genes characteristic of\n                    <jats:italic>Isl2<\/jats:italic>\n                    \u2010expressing RGCs, along with increased retinal cell death during development. These findings suggest that\n                    <jats:italic>Isl2<\/jats:italic>\n                    is required for the development and survival of\n                    <jats:italic>Isl2<\/jats:italic>\n                    \u2010expressing RGC subtypes.\n                  <\/jats:p>","DOI":"10.1002\/dneu.22978","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T05:08:54Z","timestamp":1749186534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Islet\u20102 Is Required for the Survival of Islet\u2010Expressing Retinal Ganglion Cells but Not for Their Pathfinding to the Contralateral Dorsal Lateral Geniculate Nucleus"],"prefix":"10.1002","volume":"85","author":[{"given":"Sadaf","family":"Abed","sequence":"first","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology University of California, Santa Cruz  Santa Cruz California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Feldheim","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cell, and Developmental Biology University of California, Santa Cruz  Santa Cruz California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.07.064"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.01.193"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16468"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.040"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1472928807000167"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0496\u2010376"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910306"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.8b00361"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902300406"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111040"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.03.010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.077"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010016\u20100876\u20101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896\u20106273(94)90354\u20109"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010021\u201003814\u2010w"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.009688"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1027\u201014.2014"},{"issue":"3","key":"e_1_2_9_20_1","first-page":"157","article-title":"[Physiological and Anatomical Study of the Retinogeniculate Projections in the Mouse]","volume":"296","author":"M\u00e9tin C.","year":"1983","journal-title":"Comptes Rendus Des Seances De L'academie Des Sciences. 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