{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:02:28Z","timestamp":1791298948747,"version":"4.1.0"},"reference-count":221,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Inflammasomes, particularly the NLRP3 inflammasome, play a pivotal role in mediating neuroinflammation in neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Huntington's disease (HD). Recent findings indicate that the activation of the NLRP3 inflammasome in microglia and astrocytes triggers the release of pro\u2010inflammatory cytokines, including IL\u20101\u03b2 and IL\u201018, which contribute to chronic inflammation and neuronal damage. This process accelerates neurodegeneration and exacerbates disease progression. Misfolded protein aggregates, mitochondrial dysfunction, and oxidative stress are key factors in the pathological activation of the NLRP3 inflammasome in these diseases. Recent studies have highlighted that targeting the NLRP3 inflammasome, either through direct inhibitors like MCC950 or natural compounds such as oridonin and \u03b2\u2010hydroxybutyrate, shows promise in mitigating neuroinflammation and protecting neuronal integrity. These inhibitors have demonstrated neuroprotective effects in animal models of AD, PD, and MS, presenting a new therapeutic approach for halting disease progression. However, the complexity of NLRP3 regulation requires further investigation to balance its inflammatory and protective roles. This review examines the recent advancements in NLRP3 inflammasome research and discusses potential strategies for modulating inflammasome activity to slow or prevent the progression of neurodegenerative diseases.<\/jats:p>","DOI":"10.1002\/dneu.22982","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T05:14:48Z","timestamp":1749186888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Exploring the Role of NLRP3 in Neurodegeneration: Cutting\u2010Edge Therapeutic Strategies and Inhibitors"],"prefix":"10.1002","volume":"85","author":[{"given":"Mohammed Ahmed","family":"Mustafa","sequence":"first","affiliation":[{"name":"Department of Biology, College of Education University of Samarra  Samarra Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Allied Healthcare and Sciences Vivekananda Global University  Jaipur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MS","family":"Pallavi","sequence":"additional","affiliation":[{"name":"Department of Psychology, School of Sciences JAIN (Deemed to be University)  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajashree","family":"Panigrahi","sequence":"additional","affiliation":[{"name":"Department of Microbiology IMS and SUM Hospital Siksha \u2018O\u2019 Anusandhan (Deemed to be University)  Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Nathiya","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, NIMS Institute of Pharmacy NIMS University Rajasthan  Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Graphic Era Hill University  Dehradun India"},{"name":"Centre for Promotion of Research Graphic Era Deemed to be University  Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaker","family":"Al\u2010Hasnaawei","sequence":"additional","affiliation":[{"name":"College of Pharmacy The Islamic University  Najaf Iraq"},{"name":"Department of Medical Analysis Medical Laboratory Technique College The Islamic University of Al Diwaniyah  Al Diwaniyah Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Singh","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Uttaranchal Institute of Pharmaceutical Sciences, Division of Research and Innovation Uttaranchal University  Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siya","family":"Singla","sequence":"additional","affiliation":[{"name":"Centre for Research Impact &amp; 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