{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:20:11Z","timestamp":1787761211745,"version":"build-2784847793"},"reference-count":81,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Autism spectrum disorder (ASD) is a neurodevelopmental condition influenced by genetic and environmental factors, including prenatal nutrition. This study investigates the role of Vitamin A deficiency (VAD) in exacerbating ASD\u2010like behaviors in a valproic acid (VPA)\u2010induced rat model and mitigating effects of Vitamin A supplementation (VAS). Twenty\u2010five pregnant rats were divided into five groups, with treatments including VPA exposure and VAD. Neurodevelopmental and behavioral tests, such as the rollover, negative geotaxis, gait, and open field, assessed motor coordination and social interaction in offspring. VPA and VAD groups showed impaired behaviors, motor deficits, and elevated oxidative stress, marked by reduced superoxide dismutase, catalase, and glutathione levels, alongside increased malondialdehyde, nitrite oxide, and altered acetylcholine activity. VAS partially restored antioxidant defenses and alleviated behavioral symptoms. These findings highlight the exacerbating impact of VAD on ASD\u2010like behaviors and the therapeutic potential of VAS in managing neurodevelopmental and biochemical alterations linked to ASD.<\/jats:p>","DOI":"10.1002\/dneu.22990","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T04:12:41Z","timestamp":1751861561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Vitamin A Deficiency and Supplementation on Behavioral and Oxidative Stress Markers in Male Offspring of a Valproic Acid\u2010Induced Autism Rat Model"],"prefix":"10.1002","volume":"85","author":[{"given":"Kacimi Fatima","family":"Ezzahra","sequence":"first","affiliation":[{"name":"Polydisciplinary Faculty, Biotechnology and Sustainable Development of Natural Resources Unit Sultan Moulay Slimane University  Beni Mellal Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed\u2010Day","family":"Soumia","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Unit of Neuroscience, Neuroimmunology and Behavior, Laboratory of Biology and Health Ibn Tofail University  Kenitra Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nechchadi","family":"Habiba","sequence":"additional","affiliation":[{"name":"Polydisciplinary Faculty, Biotechnology and Sustainable Development of Natural Resources Unit Sultan Moulay Slimane University  Beni Mellal Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibouzineddine","family":"Laila","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Unit of Neuroscience, Neuroimmunology and Behavior, Laboratory of Biology and Health Ibn Tofail University  Kenitra Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramchoun","family":"Mhamed","sequence":"additional","affiliation":[{"name":"Polydisciplinary Faculty, Biotechnology and Sustainable Development of Natural Resources Unit Sultan Moulay Slimane University  Beni Mellal Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berrougui","family":"Hicham","sequence":"additional","affiliation":[{"name":"Polydisciplinary Faculty, Biotechnology and Sustainable Development of Natural Resources Unit Sultan Moulay Slimane University  Beni Mellal Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azzaoui","family":"Fatima\u2010Zahra","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Unit of Neuroscience, Neuroimmunology and Behavior, Laboratory of Biology and Health Ibn Tofail University  Kenitra Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boulbaroud","family":"Samira","sequence":"additional","affiliation":[{"name":"Polydisciplinary Faculty, Biotechnology and Sustainable Development of Natural Resources Unit Sultan Moulay Slimane University  Beni Mellal Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(84)05016-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2019.08.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2012.06.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2009.939.948"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(63)90106-2"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"189","article-title":"Neuropathology of Aluminum Toxicity in Rats","volume":"47","author":"Azzaoui F.","year":"2003","journal-title":"Biology and Medicine"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2015.08.010"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.56342"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(71)90370-8"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.976799"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010019\u201001742\u20102"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010018\u20102988\u20104"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10121851"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010020\u201004611\u20103"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.8.2736"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.04.038"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08\u2010112375"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/712758"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x11311030006"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.259604"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.07.008"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.12.017.Modeling"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-i"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1051\/e3sconf\/202131901015"},{"issue":"12","key":"e_1_2_11_26_1","first-page":"2315","article-title":"Toxicity and Behavioral Outcomes of the Ethanolic Extract of Schinus terebinthifolius Raddi Fruits in Wistar Rats","volume":"12","author":"Ed\u2010Day S.","year":"2024","journal-title":"Advances in Animal and Veterinary Sciences Toxicity"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20109861(59)90090\u20106"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24616"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.02036"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3791\/53569"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010020\u201000885\u20102"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","unstructured":"Gould T. D. D. T.Dao andC. E.Kovacsics.2009.Mood and Anxiety Related Phenotypes in Mice.In Neuromethods42:1\u201320.https:\/\/doi.org\/10.1007\/978\u20101\u201060761\u2010303\u20109.","DOI":"10.1007\/978-1-60761-303-9_1"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2017.11.001"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.886244"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2304\u20103881.2016.01.02"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2006.09.002.The"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0818s25"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2019.09.09"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnrt.2022.100002"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7090258"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008524.pub4"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0892\u20100362(99)00083\u20105"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30366"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1515\/prolas\u20102016\u20100003"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016\u20102828H"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.274"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009\u20108981(78)90081\u20105"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/2047\u20109158\u20102\u201017"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010017\u20101096\u20101"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.813304"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5417497"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u20107847.70902"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2015.24.4.285"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073894"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010212671"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892\u20100362(03)00073\u20104"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/1177271917691035"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010015\u20100154\u20100"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212803523554"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1338\u201012.2013"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u2010183X.2004.00071.x"},{"key":"e_1_2_11_62_1","unstructured":"Nasri I. B. E. L.Bouhali A.Mesfiou A. E.Hessni M. E.Ghissassi andA.Ouichou.2002.Impact De La Carence En Vitamine A Sur Les Niveaux En R\u00e9tino\u00efdes Du Cerveau De Rat Biologie & Sant\u00e9 2 no.2:146\u2013155."},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci\u20102020\u20100183"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3791\/55261"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010031\u201042383\u20103_5"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258720"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900246.Significance"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093293"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2016.00104"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.04.008"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6925"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.61"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.5214\/ans.0972.7531.260106"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201039014\u20107"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00479"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.09.28.559718"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12993\u2010024\u201000251\u20100"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433\u2010021\u201001753\u20101"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065487"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.851980"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.08.091"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22990","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dneu.22990","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:46:45Z","timestamp":1773010005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":81,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/dneu.22990"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22990","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22990"}}