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This study investigated the effects of EMF exposure during different pregnancy trimesters on rat offspring trigeminal ganglia (TGs), focusing on transient receptor potential melastatin 2 (TRPM2) ion channels, and assessed the neuroprotective potential of ferrostatin\u20101 (Fer), a ferroptosis inhibitor, against EMF\u2010induced damage. Pregnant rats were exposed to 900\u00a0MHz EMF for 2\u00a0h\/day during early (1\u20137 days, EMF 1), mid (8\u201314 days, EMF 2), or late (15\u201321 days, EMF 3) gestation. Fer (2.5\u00a0\u00b5mol\/kg, i.p.) was administered immediately after daily EMF exposure in Fer treatment groups. Offspring TG tissues were analyzed on postnatal Day 28 using histopathological, immunohistochemical, and biochemical approaches. EMF exposure significantly reduced antioxidant capacity and elevated lipid peroxidation, reactive oxygen species (ROS), pro\u2010inflammatory cytokines, apoptotic markers, and TRPM2 activation, with the most pronounced alterations in mid\u2010gestation exposure. Fer administration largely normalized these parameters and reduced structural damage in TG. In conclusion, these findings suggest that prenatal EMF triggers ferroptotic\/apoptotic neurodegeneration via TRPM2, and that Fer holds promise as a neuroprotective agent.<\/jats:p>","DOI":"10.1002\/dneu.23013","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:19:46Z","timestamp":1761657586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of 900\u00a0MHz Electromagnetic Field Exposure During Different Trimesters of Pregnancy on TRPM2\u2010Mediated Ferroptosis and Neurotoxicity in the Trigeminal Ganglion of Rats: Protective Role of Ferrostatin\u20101"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-6906","authenticated-orcid":false,"given":"Yener","family":"Yaz\u011fan","sequence":"first","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine Kastamonu University  Kastamonu 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