{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:29:30Z","timestamp":1786699770065,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The clustered protocadherins (cPcdhs) are a family of \u223c60 homophilic cell adhesion molecules expressed across three gene clusters (\n                    <jats:italic>Pcdha<\/jats:italic>\n                    ,\n                    <jats:italic>Pcdhb<\/jats:italic>\n                    , and\n                    <jats:italic>Pcdhg<\/jats:italic>\n                    ) with a variety of essential roles in the developing nervous system. Some of these roles rely on specific isoforms, whereas others are more consistent with a model of isoform redundancy or a requirement for diversity. The \u03b3\u2010Pcdhs (expressed from the\n                    <jats:italic>Pcdhg<\/jats:italic>\n                    gene cluster) are particularly important for neuronal self\u2010avoidance in starburst amacrine cells in the mouse retina. Here, we used mouse mutants to test two of the C\u2010type isoforms\u2014\u03b3C4 and \u03b3C5\u2014and found that neither was required for normal self\u2010avoidance. Conversely, when we analyzed a mutant with only\u00a0\u03b3C4 intact, we found significant failures in self\u2010avoidance that could not be completely rescued by overexpression of this isoform from a transgene. We have recently found that this isoform is essential for normal neuronal survival during development, and our new findings here support the hypothesis that \u03b3C4 is specialized for the survival function at the expense of a significant role in self\u2010avoidance.\n                  <\/jats:p>","DOI":"10.1002\/dneu.70005","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T06:55:05Z","timestamp":1767077705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced Neuronal Self\u2010Avoidance in Mouse Starburst Amacrine Cells With Only One\n                    <i>Pcdhg<\/i>\n                    Isoform"],"prefix":"10.1002","volume":"86","author":[{"given":"Cathy M.","family":"McLeod","sequence":"first","affiliation":[{"name":"Department of Pharmacology Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyoung","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nazmul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille M.","family":"Hanes","sequence":"additional","affiliation":[{"name":"Department of Biology, Iowa Neuroscience Institute University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Garrett","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Department of Ophthalmology, Visual and Anatomical Sciences Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101089\u20103"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2450"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3231"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104864"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2023.09.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35242"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.09.027"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06514"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008554"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1809430115"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.01.028"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16144"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2818\u201009.2009"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1713449114"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22950"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","unstructured":"Hanes C. M. D. M.Steffen G. C.Murray R. W.Burgess J. A.Weiner andA. M.Garrett.2025. \u201cA New Mouse Mutant With a Discrete Mutation in Pcdhgc5 Reveals That the Protocadherin \u03b3C5 Isoform Is Not Essential for Dendrite Arborization in the Cerebral Cortex.\u201dPreprint bioRxiv May 28.https:\/\/doi.org\/10.1101\/2025.05.28.656572.","DOI":"10.1101\/2025.05.28.656572"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.092031"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3035\u201017.2018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2024.08.002"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201016120\u2010y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.642306"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1027\u201020.2020"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23033"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08964"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00977785"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009013\u2010y"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11305"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.027912"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2011.07587.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31665"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2313596120"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2514178122"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.70010"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010025\u201005239\u2010z"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.03.012"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.093"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.026807"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1261048"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34241"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1017\/s095252380001049x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.010"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.07.023"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.026"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004526107"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0729\u201022.2022"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.07.012"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896\u20106273(02)01090\u20105"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407931101"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)80789\u20108"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.167301"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3549\u201015.2016"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056948\u2010x"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010062111\u2010150414"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.10.009"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.70005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dneu.70005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.70005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:39:48Z","timestamp":1786696788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.70005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/dneu.70005"],"URL":"https:\/\/doi.org\/10.1002\/dneu.70005","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.05.29.656828","asserted-by":"object"}]},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2025-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70005"}}