{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:29:37Z","timestamp":1786699777878,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ischemic stroke is a prominent cause of morbidity and mortality, affecting numerous people worldwide. The exact role of Maixuekang capsule in cerebral ischemia\/reperfusion injury (CI\/RI) remains elusive. The present study aimed to delve into the neuroprotective potential of Maixuekang in CI\/RI rats. Utilizing the HREB database, leech ingredients were retrieved, while GeneCards, therapeutic target database (TTD), and DisGeNET databases were used to predict cerebral infarction targets. Search tool for the retrieval of interacting genes\/proteins (STRING) database was adopted to identify overlapping genes, and Cytoscape 3.9.1 to analyze core targets. The gene ontology (GO)\/ Kyoto encyclopedia of genes and genomes (KEGG) pathway were analyzed and neurological function was assessed via Longa scoring. The 2,3,5\u2010triphenyltetrazolium chloride (TTC), Golgi, hematoxylin and eosin (H&amp;E), and Nissl stains were adopted to observe cerebral infarction and pathological changes. The neuronal apoptosis, hypoxia inducible factor 1 alpha (HIF1A), myeloperoxidase (MPO) and inflammatory factors in rat were measured. Results suggested Maixuekang reduced the neurological function score and the cerebral infarction incidence in CI\/RI rats. After taking Maixuekang, the number of dendritic spines of CI\/RI rats increased, the neuronal damage degree in the ischemic cortical area reduced, and the neurons morphology improved. In addition, Maixuekang reduced the blood\u2013brain barrier (BBB) damage and brain tissue water content by decreasing neuronal apoptosis rate, Bax expression, neutrophil infiltration, inflammatory factor levels, and increasing Bcl2 by decreasing HIF1A in CI\/RI rat tissues. Collectively, Maixuekang could reduce neurological function, cerebral infarction rate, blood\u2013brain barrier damage, neuroinflammation and downregulates HIF1A in tissues of CI\/RI rats.<\/jats:p>","DOI":"10.1002\/dneu.70008","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:02:16Z","timestamp":1767808936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elucidating the Neuroinflammatory Modulatory Mechanisms of Maixuekang Capsule via Network Pharmacology in Cerebral Ischemia\/Reperfusion Injury Rats"],"prefix":"10.1002","volume":"86","author":[{"given":"Huihui","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang Hebei P.R. China"},{"name":"Hebei Key Laboratory of Vascular Homeostasis and Hebei Collaborative Innovation Center for Cardio\u2010Cerebrovascular Disease  Shijiazhuang Hebei P.R. China"},{"name":"The Key Laboratory of Neurology Hebei Medical University, Ministry of Education  Shijiazhuang Hebei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shijiazhuang Traditional Chinese Medicine Hospital  Shijiazhuang Hebei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexia","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang Hebei P.R. China"},{"name":"Hebei Key Laboratory of Vascular Homeostasis and Hebei Collaborative Innovation Center for Cardio\u2010Cerebrovascular Disease  Shijiazhuang Hebei P.R. China"},{"name":"The Key Laboratory of Neurology Hebei Medical University, Ministry of Education  Shijiazhuang Hebei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medical The Second Hospital of Hebei Medical University  Shijiazhuang Hebei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang Hebei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0114-1668","authenticated-orcid":false,"given":"Xiangjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Hospital of Hebei Medical University  Shijiazhuang Hebei P.R. China"},{"name":"Hebei Key Laboratory of Vascular Homeostasis and Hebei Collaborative Innovation Center for Cardio\u2010Cerebrovascular Disease  Shijiazhuang Hebei P.R. China"},{"name":"The Key Laboratory of Neurology Hebei Medical University, Ministry of Education  Shijiazhuang Hebei P.R. 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