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Traumatic events, natural disasters, and accidents often cause these complex injuries. Recent studies highlight the neurogenic potential of dexamethasone, retinoic acid, and umbilical cord blood stem cells in promoting nerve regeneration. Therefore, the aim of this study was to design electrospun conduits based on PLCL, gelatin, and collagen, along with dexamethasone, retinoic acid, carboxymethyl chitosan, and umbilical cord blood cells to repair sciatic nerve injuries. The chemical and physical properties of the conduits, in addition to biocompatibility and cytotoxicity, were evaluated with different experiments. Finally, the conduits were implanted into a 10\u00a0mm defect in the mouse sciatic nerve, and tissue regeneration was assessed after 3 months by related tests. The results showed that the presence of dexamethasone in the conduit designed improved biocompatibility, wettability, degradation rate, tensile strength, and increased cell viability. After seeding the umbilical cord blood cells on the conduit, the results showed good efficacy of the conduit, improving sensory and motor function and increasing nerve regeneration. These results indicate the potential of the resulting conduits as a promising tool for repairing nerve injuries and clinical trials.<\/jats:p>","DOI":"10.1002\/dneu.70022","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:37:08Z","timestamp":1777523828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional Electrospun Nerve Conduits Enriched With Stem Cells and Bioactive Molecules for Sciatic Nerve Regeneration"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-3900","authenticated-orcid":false,"given":"Tayebeh Sadat","family":"Tabatabai","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine Shahroud University of Medical Sciences  Shahroud Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4214-6502","authenticated-orcid":false,"given":"Morteza","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3889-5642","authenticated-orcid":false,"given":"Amir","family":"Atashi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, School of Applied Medical Science Shahroud University of Medical Sciences  Shahroud Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1947-1222","authenticated-orcid":false,"given":"Arian","family":"Ehterami","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine (IREM) University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4768-2577","authenticated-orcid":false,"given":"Mohammad Kamalabadi","family":"Farahani","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Research Center Shahroud University of Medical Sciences  Shahroud Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-6743","authenticated-orcid":false,"given":"Nariman Rezaei","family":"Kolarijani","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Shahroud University of Medical Sciences  Shahroud Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6283-8181","authenticated-orcid":false,"given":"Majid","family":"Salehi","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Research Center Shahroud University of Medical Sciences  Shahroud Iran"},{"name":"Department of Tissue Engineering, School of Medicine Shahroud University of Medical Sciences  Shahroud Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14030397"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.2758"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113816128374388250603063716"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pat.5263"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123459"},{"key":"e_1_2_10_7_1","first-page":"405","article-title":"Peripheral Nerve Conduits: Technology Update","volume":"7","author":"Arslantunali D.","year":"2014","journal-title":"Medical Devices: Evidence and Research"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/BME-221410"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2021.104650"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5812\/jhgg-122860"},{"issue":"1","key":"e_1_2_10_11_1","first-page":"111","article-title":"The Controlled Release of Dexamethasone Sodium Phosphate From Bioactive Electrospun PCL\/Gelatin Nanofiber Scaffold","volume":"18","author":"Boroojen F. 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