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M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020733","name":"Sino-Danish Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and is associated with attention deficits, hyperactivity, anxiety, impulsivity, and repetitive behaviors. The disorder results from transcriptional silencing of the\n                    <jats:italic>FMR1<\/jats:italic>\n                    gene, leading to loss of fragile X messenger ribonucleoprotein (FMRP), an RNA\u2010binding protein that regulates local dendritic translation by repressing ribosomal activity. To examine how impaired local protein synthesis affects dendritic organization, we used Golgi\u2013Cox staining to analyze hippocampal CA1 principal neurons across four developmental stages (P14\u201321, P30\u201340, P60\u201380, and P120\u2013150) in an FXS mouse model. We identified a progressive reduction in dendritic complexity, reflected by decreased Sholl intersections and reduced dendritic branch number and length. In contrast, spine density was increased in both apical and basal dendrites during early development but normalized to wild\u2010type levels in adulthood. Collectively, these structural alterations are likely to disrupt neural circuit development, with downstream consequences for cognition and behavior characteristic of FXS.\n                  <\/jats:p>","DOI":"10.1002\/dneu.70030","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:00:04Z","timestamp":1776236404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010Related Decline in Dendritic Architecture of Hippocampal CA1 Principal Neurons in a Mouse Model of Fragile X Syndrome"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0776-1746","authenticated-orcid":false,"given":"Neelam Noorie Umar","family":"Farooqi","sequence":"first","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"},{"name":"Core Center for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Pathology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-4646","authenticated-orcid":false,"given":"Jens R.","family":"Nyengaard","sequence":"additional","affiliation":[{"name":"Core Center for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Pathology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8417-4400","authenticated-orcid":false,"given":"Tue G.","family":"Banke","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0693-147"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2018.10.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36241"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00568-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508995102"},{"key":"e_1_2_11_7_1","first-page":"5401","article-title":"Abnormal Dendritic Spines in Fragile X Knockout Mice: Maturation","volume":"94","author":"Comery T. 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