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This behavior, crucial for the offspring's neurodevelopment, is regulated by the hypothalamic\u2010pituitary\u2010adrenal (HPA) axis and prolactin. This study investigated the effect of gestational ZIKV inoculation on maternal care in\n                    <jats:italic>Wistar<\/jats:italic>\n                    rats and its relationship with prolactin and corticosterone levels. Fifty\u2010six females were inoculated intraperitoneally on gestational day 9 (G9) with ZIKV (28 ZK group) or vehicle (28 CT group). Blood and hypothalamus samples from a set of these animals (\n                    <jats:italic>n<\/jats:italic>\n                    = 16\/group) were collected 24 h postpartum to quantify corticosterone and prolactin levels by ELISA. Maternal behavior was evaluated on postnatal days 4 and 8 (\n                    <jats:italic>n<\/jats:italic>\n                    = 12\/group). ZK rats demonstrated impaired maternal care compared to CT rats. Furthermore, 24 h postpartum, ZK rats had significantly lower levels of serum and hypothalamic corticosterone, and serum prolactin. The findings suggest that gestational ZIKV inoculation compromises maternal behavior in\n                    <jats:italic>Wistar<\/jats:italic>\n                    rats, concomitant with an alteration in the hormonal profile in the immediate postpartum period. The study is pioneering in demonstrating that ZIKV affects crucial components for the regulation of maternal behavior, reinforcing the need for further research to elucidate the mechanism in the maternal brain and develop targeted therapies.\n                  <\/jats:p>","DOI":"10.1002\/dneu.70053","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:41:39Z","timestamp":1783680099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zika Virus Inoculation During Pregnancy Impaired Maternal Care and Altered Prolactin and Corticosterone Levels in Rats"],"prefix":"10.1002","volume":"86","author":[{"given":"Meirylanne","family":"Gomes\u2010da\u2010Costa","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Neuroci\u00eancias, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande 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Rio Grande do Sul Brazil"},{"name":"Departamento de Ci\u00eancias Morfol\u00f3gicas, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Barth","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Morfol\u00f3gicas, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris Krebs","family":"Danilevicz","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Muterle","family":"Varela","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Fumaco","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Michel","family":"Roehe","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul  Porto Alegre Rio Grande do Sul 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