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Although low to moderate prenatal alcohol exposure (PAE) is a prevalent type of exposure, the developmental trajectory of auditory processing deficits resulting from this level of exposure remains unknown. To examine the effects of PAE in the auditory system, we utilized the maternal voluntary alcohol consumption paradigm to model chronic low to moderate PAE throughout gestation. We measured auditory brainstem responses (ABRs) in juvenile mice (postnatal day 16\u201319) and longitudinally across early adolescence (4\u20135 weeks), late adolescence (7\u20138 weeks), and young adulthood (12\u201314 weeks). ABR abnormalities were first observed in juvenile PAE mice. The effects of PAE on brainstem auditory processing were most prominent in early adolescence, largely dissipated in late adolescence, and showed a reemergence in early adulthood. PAE mice showed elevated ABR thresholds, prolonged wave latencies, and reduced wave amplitudes. Ratios of ABR peak 3 relative to the first ABR peak indicated that the auditory brainstem pathways were hyperactive in PAE mice. The amplitude ratio was found to be elevated from early adolescence to early adulthood, suggesting that PAE has a persistent effect on auditory processing. We found a significant correlation between the amplitude ratios in early adolescent PAE mice and dam ethanol consumption, which point toward dose\u2010dependent brainstem gain dysregulation. Our study shows multilevel auditory alterations highlighting the vulnerability of central auditory pathways to PAE and fills an important gap in understanding auditory processing deficits in a clinically relevant exposure model.<\/jats:p>","DOI":"10.1002\/dneu.70059","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:07:26Z","timestamp":1789535246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Developmental Trajectory of Auditory Brainstem Deficits in a Mouse Model of Fetal Alcohol Spectrum Disorders"],"prefix":"10.1002","volume":"86","author":[{"given":"Michael","family":"Douchey","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Huntwork","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassidy","family":"Sandstedt","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragunathan","family":"Padmashri","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2182\/cjot.2012.79.1.8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199213"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901390202"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"e132","article-title":"Profile of the First 1,400 Patients Receiving Diagnostic Evaluations for Fetal Alcohol Spectrum Disorder at the Washington State Fetal Alcohol Syndrome Diagnostic & Prevention Network","volume":"17","author":"Astley S. 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