{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T10:34:43Z","timestamp":1792924483081,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1145295"],"award-info":[{"award-number":["1145295"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Maternal infection\u2010induced inflammation during pregnancy is associated with adverse neurodevelopment. Rytvela, an allosteric IL\u20101 receptor antagonist, reduces IL\u20101\u03b2\u2010mediated pathology in fetal rodents and sheep. However, its effects on TLR3\u2010mediated inflammation and subsequent offspring growth and behavior remain unclear. Using precocial spiny mice, the primary outcome of this study was to examine whether rytvela could attenuate the acute maternal inflammatory response to mid\u2010gestation exposure to polyinosinic:polycytidylic acid (Poly(I:C)). Secondary offspring outcomes included postnatal growth and behavior. At gestational day 20 (term = 39 days), pregnant mice received two intraperitoneal injections, 4 h apart, of saline (0.9% w\/v,\n                    <jats:italic>n<\/jats:italic>\n                    = 14), Poly(I:C) (12\u00a0mg\/kg,\n                    <jats:italic>n<\/jats:italic>\n                    = 14), or Poly(I:C) + rytvela (12\u00a0mg\/kg + 3\u00a0mg\/kg, respectively,\n                    <jats:italic>n<\/jats:italic>\n                    = 14). Ten dams\/group were culled 8 h after dose 1 to assess inflammatory responses. The remainder (\n                    <jats:italic>n<\/jats:italic>\n                    = 4 dams\/group) were delivered at term. Offspring (control\n                    <jats:italic>n<\/jats:italic>\n                    = 7, Poly(I:C)\n                    <jats:italic>n<\/jats:italic>\n                    = 8, Poly(I:C) + rytvela\n                    <jats:italic>n<\/jats:italic>\n                    = 11) growth was monitored and behavioral testing undertaken from postnatal day (PND) 3\u201345. Poly(I:C) increased maternal serum (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.01) and amniotic fluid (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003) IL\u20101\u03b2, and upregulated\n                    <jats:italic>Il1b<\/jats:italic>\n                    ,\n                    <jats:italic>Il6<\/jats:italic>\n                    and\n                    <jats:italic>Tnf<\/jats:italic>\n                    expression in the spleen and thymus. Rytvela reduced IL\u20101\u03b2 levels but did not attenuate elevated cytokine gene expression. Poly(I:C) slowed postnatal growth (PND 18\u201327,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), which recovered earlier with rytvela. Poly(I:C) exposure did not alter offspring behavior in tests completed to PND 45. However, Poly(I:C) + rytvela offspring showed reduced locomotor activity (distance:\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001; velocity:\n                    <jats:italic>p<\/jats:italic>\n                    = 0.021). In conclusion, rytvela attenuated the primary inflammatory response to Poly(I:C), promoting earlier postnatal growth recovery despite persistent cytokine gene expression. Reduced locomotor activity after prenatal rytvela exposure warrants further investigation.\n                  <\/jats:p>","DOI":"10.1002\/dneu.70064","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:45:31Z","timestamp":1789713931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal and Postnatal Effects of Poly I:C\u2010Induced Intrauterine Inflammation and Rytvela, a Non\u2010Competitive IL\u20101R Antagonist, in the Pregnant Spiny Mouse"],"prefix":"10.1002","volume":"86","author":[{"given":"Nhi T.","family":"Tran","sequence":"first","affiliation":[{"name":"The Ritchie Centre, Department of Obstetrics and Gynaecology Monash University  Clayton Victoria Australia"},{"name":"Hudson Institute of Medical Research  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Kamareddine","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Department of Obstetrics and Gynaecology Monash University  Clayton Victoria Australia"},{"name":"Hudson Institute of Medical Research  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Bellofiore","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Department of Obstetrics and Gynaecology Monash University  Clayton Victoria Australia"},{"name":"Hudson Institute of Medical Research  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Olson","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Pediatrics, and Physiology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Chemtob","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Universit\u00e9 de Montr\u00e9al, Research Center, CHU Sainte\u2010Justine  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Robertson","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomedical Science Adelaide University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Keelan","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey J.","family":"Ellery","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Department of Obstetrics and Gynaecology Monash University  Clayton Victoria Australia"},{"name":"Hudson Institute of Medical Research  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-83"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-83"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.12.016"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbj052"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.8.774"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.3.438"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.4.767"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033453"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(89)90055-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03327252"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1071976"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2025.104520"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.02.007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00056-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2016.22"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44999"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.10.007"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.04.012"},{"issue":"1","key":"e_1_2_11_20_1","first-page":"9","article-title":"The Biology and Husbandry of the African Spiny Mouse (Acomys cahirinus) and the Research Uses of a Laboratory Colony","volume":"55","author":"Haughton C. 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