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Decades of research have demonstrated that antigen\u2010presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and\/or suppressing T cell activation. Nevertheless, the exact subsets of APCs involved in the presentation of antigens to T cells remains under debate. Recent exciting studies have described several subsets of ROR\u03b3t (Retinoic acid\u2010related orphan receptor gamma t)\u2010APCs that have key roles in regulating immune responses and oral tolerance. 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