{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T03:00:26Z","timestamp":1768100426620,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T00:00:00Z","timestamp":1274918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spiramycin (SPY) is a medium\u2010spectrum antibiotic with high effectiveness against Gram\u2010positive bacteria. The voltammetric behaviour of spiramycin was studied using differential pulse polarography (DPP) and square wave polarography (SWP). The drug in Britton\u2010Robinson buffer (pH 11.5) is reduced at \u2212 1.45 V, giving rise to a well\u2010defined cathodic peak using hanging mercury drop electrode (HMDE) versus Ag\/AgCl electrode. This peak is attributed to the reduction of the aldehyde group. The results proved that the reduction of SPY is an irreversible diffusion\u2010controlled process. The diffusion current\u2010concentration relationship was shown to be rectilinear over the range of 20\u201380 and 0.8\u201380 \u00b5g ml<jats:sup>\u22121<\/jats:sup> using DPP and SWP modes, respectively, with detection limit of 8.5 \u00b5g ml<jats:sup>\u22121<\/jats:sup> (1.01 \u00d7 10<jats:sup>\u22125<\/jats:sup> M) and 0.46 \u00b5g ml<jats:sup>\u22121<\/jats:sup> (5.46 \u00d7 10<jats:sup>\u22127<\/jats:sup> M) for DPP and SWP modes, respectively. A mechanism is postulated for the reduction of SPY. The proposed techniques were successfully applied to the determination of the studied compound either in pure form or in its formulation. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.137","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T10:06:04Z","timestamp":1274954764000},"page":"392-396","source":"Crossref","is-referenced-by-count":6,"title":["Electrochemical study of spiramycin and its determination in pharmaceutical preparation"],"prefix":"10.1002","volume":"2","author":[{"given":"Rasha M.","family":"Youssef","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadir M.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(03)00205-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/dta.83"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(98)00276-3"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02491832"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2004.04.042"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.04.019"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.10.033"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150170212"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-008-0865-2"},{"key":"e_1_2_5_11_2","unstructured":"C.Sun R.Yu Q.Yang S.Sheng X.ZhaoYaoxue Xuebao 1987 22 515."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/713609162"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00229a026"},{"key":"e_1_2_5_14_2","first-page":"195","volume-title":"Modern Polarographic Methods in Analytical Chemistry","author":"Bond A. 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