{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:55:24Z","timestamp":1788825324084,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Since the introduction of synthetic heroin, designer drugs have been increasing in prevalence in the United States drug market over the past few decades. Recently, \u2018legal highs\u2019 sold as \u2018bath salts\u2019 have become a household term for one such class of designer drugs. While a number of federal and state bans have been enacted, the abuse of these designer drugs still continues. Few assays have been developed for the comprehensive detection of such compounds, so it is important to investigate how they may or may not react in presumptive screens, i.e. pre\u2010existing commercial immunoassays. In this experiment, 16 different ELISA reagents were evaluated to determine the cross\u2010reactivity of 30 designer drugs, including 24 phenylethylamines (including 8 cathinone derivatives), 3 piperazines, and 3 tryptamines. Cross\u2010reactivity towards most drugs was &lt;4% in assays targeting amphetamine or methamphetamine. Compounds such as MDA, MDMA, ethylamphetamine, and \u03b1\u2010methyltryptamine demonstrated cross\u2010reactivities in the range of 30\u2013250%, but data were consistent with both manufacturer's inserts and published literature. When tested against the Randox Mephedrone\/Methcathinone kit, cathinone derivatives demonstrated cross\u2010reactivity at concentrations as low as 150 ng\/ml. Since this same reagent did not cross\u2010react with other amphetamine\u2010like compounds, it opens the possibility to screen post\u2010mortem specimens without the interference of putrefactive amines. All other assays demonstrated essentially no cross\u2010reactivity towards any of the analytes evaluated. Given these results, a great need exists for more broad\u2010range screening techniques to be applied when analyzing biological specimens by immunoassays for drugs of abuse, specifically the more recent designer drugs. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.1489","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T17:56:55Z","timestamp":1368640615000},"page":"716-727","source":"Crossref","is-referenced-by-count":60,"title":["Cross\u2010reactivity of designer drugs, including cathinone derivatives, in commercial enzyme\u2010linked immunosorbent assays"],"prefix":"10.1002","volume":"6","author":[{"given":"Madeleine J.","family":"Swortwood","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry and International Forensic Research Institute Florida International University  Miami FL 33199 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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