{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:47:15Z","timestamp":1760888835760,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2013,8,15]],"date-time":"2013-08-15T00:00:00Z","timestamp":1376524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>The concept of a \u2018derivative\u2019 is used widely in chemistry, where its precise meaning depends on the circumstances. However, numerous examples of derivative also occur in domestic drugs legislation, some of which stem from the 1961 United Nations Single Convention on Narcotic Drugs. There is a commonly held view that only \u2018first\u2010order\u2019 derivatives should be considered: substances that can be created from a parent structure in a single chemical reaction. In other words, \u2018derivatives of derivatives\u2019 are excluded. However, some substances related to ecgonine (e.g. 2\u2010carbomethoxytropinone) are clearly convertible to cocaine, even though this may require more than one reaction step. It follows that 2\u2010carbomethoxytropinone is a controlled drug, a situation that most chemists would regard as perverse. A more extreme example of the complexity of \u2018derivative\u2019 is shown by the conversion of thebaine to buprenorphine. Even though this requires six or more stages, the US Drug Enforcement Administration successfully argued in a 1986 case that for the purposes of the Controlled Substances Act, the number of steps required was irrelevant; buprenorphine was a derivative of thebaine. Because the term derivative is rarely defined in statutes, the legal status of some substances, such as 2\u2010bromo\u2010LSD, is uncertain. Although a number of definitions of derivative can be found in the chemical literature, no single definition is adequate to describe all situations where it occurs in legislation. Unless qualified, it is suggested that the term derivative should be avoided in any future legislation. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.1523","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T00:29:58Z","timestamp":1376612998000},"page":"879-883","source":"Crossref","is-referenced-by-count":7,"title":["Drug laws and the 'derivative' problem"],"prefix":"10.1002","volume":"6","author":[{"given":"Leslie A.","family":"King","sequence":"first","affiliation":[{"name":"27 Ivar Gardens Basingstoke RG24 8YD UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Ujv\u00e1ry","sequence":"additional","affiliation":[{"name":"iKem BT, B\u00faza utca 32 H\u20101033 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon D.","family":"Brandt","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences Liverpool John Moores University  Byrom Street Liverpool L3 3AF UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,15]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"League of Nations.Publications of Treaties and International Engagements registered with the Secretariat of the League of Nations No. 222. 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