{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:25:12Z","timestamp":1791321912644,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T00:00:00Z","timestamp":1376438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>Nine important 1,4\u2010benzodiazepines and zolpidem were characterized by liquid chromatography\u2010mass spectrometry using a multimode ionization source able to generate ions using both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), and a single quadrupole mass analyzer. An optimum chromatographic separation was applied for all target compounds in less than 8 minutes using a Zorbax Eclipse Plus column (100 \u00d7 4.6 mm, 3.5 \u00b5m) kept at 35\u00b0C and a 0.3% HCOOH\/ACN\/IPA (61:34:5) mobile phase pumped at 1 ml\/min. Optimization of LC\u2010MS method generated low limit of quantitation (LOQ) values situated in the range 0.3\u201320.5 ng\/ml. Comparison between differences in method sensitivity, under specified chromatographic conditions, when using ESI\u2010only, APCI\u2010only, and simultaneous ESI\u2010APCI ionization with such a multimode source was discussed. Mixed ESI\u2010APCI(+) mode proved to be the most sensitive ionization generating an average 35% detector response increase compared to ESI\u2010only ionization and 350% detector response increase with respect to APCI\u2010only ionization. Characterization of the nine benzodiazepines and zolpidem concerning their MS fragmentation pathway following \u2018in\u2010source\u2019 collision\u2010induced dissociation is discussed in detail and some general trends regarding these fragmentations are set. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.1526","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T02:29:55Z","timestamp":1376447395000},"page":"439-450","source":"Crossref","is-referenced-by-count":23,"title":["Simultaneous ESI\u2010APCI(+) ionization and fragmentation pathways for nine benzodiazepines and zolpidem using single quadrupole LC\u2010MS"],"prefix":"10.1002","volume":"6","author":[{"given":"Toma","family":"Galaon","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Chemistry, University of Bucharest  Sos. Panduri, no. 90 Bucharest 050663 Romania"},{"name":"Laboratory of Colloids, \u201cIlie Murgulescu\u201d Institute of Physical Chemistry Romanian Academy  Spl. Independen\u0163ei, No. 202 060021 Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Vacaresteanu","sequence":"additional","affiliation":[{"name":"Laboratory of Colloids, \u201cIlie Murgulescu\u201d Institute of Physical Chemistry Romanian Academy  Spl. Independen\u0163ei, No. 202 060021 Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan\u2010Florin","family":"Anghel","sequence":"additional","affiliation":[{"name":"Laboratory of Colloids, \u201cIlie Murgulescu\u201d Institute of Physical Chemistry Romanian Academy  Spl. 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