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Direct analysis in real time mass spectrometry (DART\u2010MS) is an ambient ionization method that was employed to rapidly identify the presence of DMAA in various samples without any extraction or preparations whatsoever. DMAA was first identified in supplements, sampled directly in their solid forms. Furthermore, DMAA was detected directly in urine over 48 h as a means of indicating recent abuse of the substance. DART\u2010MS analysis is instantaneous, and coupled with the high mass accuracy associated with the time\u2010of\u2010flight mass analyzer, results in unequivocal identification of the presence of DMAA. These features demonstrate DART\u2010MS as an attractive potential alternative screening method for the presence of drugs and medications or for toxicological investigations. 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