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The method is based on the development of blue\u2010coloured product due to the reduction of tungstate and\/or molybdate in Folin\u2010Ciocalteu reagent by amoxicillin and ampicillin in alkaline medium. The chromogenic reaction has \u03bb<jats:sub>max<\/jats:sub> at 720 and 740 nm with molar absorptivity 1.6295 \u00d7 10<jats:sup>4<\/jats:sup> and 0.1085 \u00d7 10<jats:sup>4<\/jats:sup> l mol<jats:sup>\u22121<\/jats:sup> cm<jats:sup>\u22121<\/jats:sup> in the Beer's Law range 2\u201310 \u00b5g mL<jats:sup>\u22121<\/jats:sup> and 10\u201370 \u00b5g mL<jats:sup>\u22121<\/jats:sup> for amoxicillin and ampicillin, respectively. The method is reproducible, quick, inexpensive, and particularly helpful in determining the drug content in commercial dosage forms. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.157","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T08:47:07Z","timestamp":1285231627000},"page":"503-506","source":"Crossref","is-referenced-by-count":7,"title":["Spectrophotometric determination of penicillins in pure and pharmaceutical formulations using Folin\u2010Ciocalteu reagent"],"prefix":"10.1002","volume":"2","author":[{"given":"Dhruv K.","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunjan","family":"Maheshwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.53.1003"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0141-8130(03)00081-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-9140(97)00253-1"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0141-8130(99)00052-5"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2009.08.104"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/00032710600611525"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.02.012"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(00)00463-5"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(00)00080-X"},{"key":"e_1_2_5_11_2","first-page":"190","volume":"2","author":"Giang D. 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