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The novel nanoring carboxyl\u2010functionalized paramagnetic molecularly imprinted polymer (NR\u2010CF\u2010Mag\u2010MIP) was synthesized by ultrasound\u2010assisted suspension polymerization, using ME as a template molecule, methacrylic acid as a functional monomer, and divinylbenzene as a cross\u2010linking agent. The NR\u2010CF\u2010Mag\u2010MIP was used as the d\u2010<jats:italic>\u03bc<\/jats:italic>\u2010SPE sorbent to extract ME from human plasma samples. The obtained results demonstrated the higher extraction capacity of NR\u2010CF\u2010Mag\u2010MIP with recoveries between 97.6 and 101%. The limits of quantification (LOQs) for ME was 0.015\u2009\u00b5g\/L. Validation results on linearity, specificity, accuracy, precision, and stability, as well as on application to the analysis of samples taken up to 480\u2009h after oral administration of 20\u2009mg (two 10\u2009mg capsules) of ME in healthy volunteers demonstrated the applicability to bioequivalence studies. 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