{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:20:34Z","timestamp":1778559634892,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>3,4\u2010Methylenedioxymethamphetamine (MDMA, ecstasy) is still a widely used illicit designer drug and its detection in different matrices is of major importance for forensic purposes (e.g.\u2009driving under the influence) as well as for workplace drug testing or abstinence control. Established analytical methods for the determination of MDMA are mainly employing high performance liquid chromatography (HPLC) or gas chromatography (GC) coupled to mass spectrometric detection. Matrix assisted laser desorption\/ionization\u2010triple quadrupole\u2010tandem mass spectrometry (MALDI\u2010QqQ\u2010MS\/MS) is so far rarely used in forensics and offers an ultrafast high\u2010throughput platform. The Quantisal\u2122 Oral Fluid Collection Device was used for sample collection. After addition of the deuterated internal standard and a carbonate buffer (0.75\u2009M Na<jats:sub>2<\/jats:sub>CO<jats:sub>3<\/jats:sub>), oral fluid samples were liquid\u2010liquid extracted (ButOAc\/EtOAc, 1:1). As little as 1 microlitre of a mixture of this extract and the MALDI matrix (alpha\u2010cyano\u20104\u2010hydroxycinnamic acid) was spotted onto the MALDI plate and could directly be analyzed. With MALDI omitting chromatographic separation, very short analysis times of about 10\u2009s per sample were possible. The method was developed and validated according to international guidelines including specificity, recovery, matrix effects, accuracy and precision, stabilities and limit of quantification. All validation criteria were fulfilled except for ion suppression\/enhancement. Comparison with a routine liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS) method showed good agreement of the results. Applicability of the method was shown by analyzing about 250 oral fluid samples collected after controlled administration of 125\u2009mg MDMA in a pharmacokinetic study. The whole lot of samples could be analyzed in less than 1\u2009h, proving the ultra\u2010high\u2010speed of the method. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.1810","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T00:37:06Z","timestamp":1432082226000},"page":"235-240","source":"Crossref","is-referenced-by-count":11,"title":["Development of a high\u2010speed MALDI\u2010triple quadrupole mass spectrometric method for the determination of 3,4\u2010methylenedioxymethamphetamine (MDMA) in oral fluid"],"prefix":"10.1002","volume":"8","author":[{"given":"Michael","family":"Poetzsch","sequence":"first","affiliation":[{"name":"Department of Forensic Pharmacology and Toxicology, ZIFM \u2010 Zurich Institute of Forensic Medicine University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea E.","family":"Steuer","sequence":"additional","affiliation":[{"name":"Department of Forensic Pharmacology and Toxicology, ZIFM \u2010 Zurich Institute of Forensic Medicine University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric M.","family":"Hysek","sequence":"additional","affiliation":[{"name":"Departement of Biomedicine, Division of Clinical Pharmacology and Toxicology University Hospital Basel, University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias E.","family":"Liechti","sequence":"additional","affiliation":[{"name":"Departement of Biomedicine, Division of Clinical Pharmacology and Toxicology University Hospital Basel, University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Department of Forensic Pharmacology and Toxicology, ZIFM \u2010 Zurich Institute of Forensic Medicine University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nst161"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.78"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145713001132"},{"key":"e_1_2_6_5_1","unstructured":"European Monitoring Centre of Drug and Drug Addiction (EMCDDA).European Drug Report 2013 \u2010 Trends and Q3 Developments. 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