{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:57:19Z","timestamp":1760385439794,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Androgenic anabolic steroid (AAS) abuse is associated with changes in cardiac electrophysiology. Recently heart rate corrected QT interval (QTc) has been suggested as a method of screening for AAS use in athletes despite conflicting reports. This study aimed to further investigate the effect of AAS on QTc in a cohort of long\u2010term AAS users in whom the affects may be more pronounced. Using a cross\u2010sectional cohort design with AAS using resistance trained athletes (AS n\u2009=\u200915) and a group of non\u2010AAS using resistance trained, age matched controls (C n\u2009=\u200915). AS had a long history of AAS use (18\u2009\u00b1\u20092\u2009yrs) and AS and C both had &gt;19\u2009years of resistance training. Participants underwent a resting electrocardiogram (ECG), from which, the QTc interval was calculated using the Bazett formula. The main outcome measure was significant differences in mean corrected QTc between groups. A secondary outcome was to calculate a QTc that best differentiated between C and AS. Results indicated that QTc was shorter in AS than in C (382.0\u2009\u00b1\u200921.01\u2009ms versus 409\u2009\u00b1\u200918.77\u2009ms for AS and C respectively p\u2009&lt;\u20090.001). Chi squared analyses revealed a greater incidence of QTc\u2009&lt;\u2009380\u2009ms in AS versus C p\u2009&lt;\u20090.01, specificity 93% sensitivity 60%). In conclusion these results supports previous findings that AAS use causes a reduction in QTc, however, the specificity and sensitivity in our sample is lower than reported previously and precludes use as a screening tool. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.1826","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T19:35:54Z","timestamp":1433964954000},"page":"120-122","source":"Crossref","is-referenced-by-count":3,"title":["Prolonged androgenic anabolic steroid (AAS) induced QT interval shortening: a suitable screening tool?"],"prefix":"10.1002","volume":"8","author":[{"given":"Nicholas","family":"Sculthorpe","sequence":"first","affiliation":[{"name":"Institute of Clinical Exercise and Health Science, School of Science and Sport University of the West of Scotland  Hamilton Scotland ML3 0BJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Taylor","sequence":"additional","affiliation":[{"name":"Institute of Sport and Physical Activity Research University of Bedfordshire  Bedford MK41 9EA UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fergal M.","family":"Grace","sequence":"additional","affiliation":[{"name":"Institute of Clinical Exercise and Health Science, School of Science and Sport University of the West of Scotland  Hamilton Scotland ML3 0BJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0247-x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2012-091186"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-010-9090-y"},{"key":"e_1_2_5_5_1","first-page":"35","volume-title":"Annals of Noninvasive Clectrocardiology: Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc","author":"Bigi M. 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