{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:29:37Z","timestamp":1761611377049,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Two different analytical techniques, ultra\u2010high performance supercritical fluid chromatography\u2010tandem mass spectrometry (UHPSFC\u2010MS\/MS) and reversed phase ultra\u2010high performance liquid chromatography\u2010tandem mass spectrometry (UHPLC\u2010MS\/MS), were used for the determination of two synthetic cannabinoids and eleven metabolites in urine; AM\u20102201\u2009N\u20104\u2010OH\u2010pentyl, AM\u20102233, JWH\u2010018\u2009N\u20105\u2010OH\u2010pentyl, JWH\u2010018\u2009N\u2010pentanoic acid, JWH\u2010073\u2009N\u20104\u2010OH\u2010butyl, JWH\u2010073\u2009N\u2010butanoic acid, JWH\u2010122\u2009N\u20105\u2010OH\u2010pentyl, MAM\u20102201, MAM\u20102201\u2009N\u20104\u2010OH\u2010pentyl, RCS\u20104\u2009N\u20105\u2010OH\u2010pentyl, UR\u2010144 degradant N\u2010pentanoic acid, UR\u2010144\u2009N\u20104\u2010OH\u2010pentyl, and UR\u2010144\u2009N\u2010pentanoic acid. Sample preparation included a liquid\u2010liquid extraction after deconjugation with \u00df\u2010glucuronidase. The UHPSFC\u2010MS\/MS method used an Acquity UPC<jats:sup>2 TM<\/jats:sup> BEH column with a mobile phase consisting of CO<jats:sub>2<\/jats:sub> and 0.3% ammonia in methanol, while the UHPLC\u2010MS\/MS method used an Acquity UPLC\u00ae BEH C<jats:sub>18<\/jats:sub> column with a mobile phase consisting of 5\u2009mM ammonium formate (pH\u200910.2) and methanol. MS\/MS detection was performed with positive electrospray ionization and two multiple reaction monitoring transitions. Deuterated internal standards were used for six of the compounds. Limits of quantification (LOQs) were between 0.04 and 0.4\u2009\u00b5g\/L. Between\u2010day relative standard deviations at concentrations\u2009\u2265\u2009LOQ were \u226420%, with biases within \u00b119%. Recoveries ranged from 40 to 90%. Corrected matrix effects were within 100\u2009\u00b1\u200910%, except for MAM\u20102201 with UHPSFC\u2010MS\/MS, and for UR\u2010144\u2009N\u2010pentanoic acid and MAM\u20102201\u2009N\u20104\u2010OH\u2010pentyl with UHPLC\u2010MS\/MS. Elution order obtained by UHPSFC\u2010MS\/MS was almost opposite to that obtained by UHPLC\u2010MS\/MS, making this instrument setup an interesting combination for screening and confirmation analyses in forensic cases. The UHPLC\u2010MS\/MS method has, since August 2014, been successfully used for confirmation of synthetic cannabinoids in urine samples revealing a positive immunoassay screening result. 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