{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:02:55Z","timestamp":1789819375868,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministerio de Sanidad, Plan Nacional Sobre Drogas, Gobierno de Espa\u00f1a","award":["2011\/097"],"award-info":[{"award-number":["2011\/097"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Drug exposure during pregnancy constitutes a major legal issue and a public health concern. Drug and metabolite determination in biological matrices from mother and newborn is an objective indication of prenatal drug exposure. However, limited data are available regarding the interpretation of these analytical results in terms of window of detection and degree of exposure. We collected paired maternal hair, meconium, placenta, and umbilical cord from 727 mother\u2010newborn dyads. We analyzed these specimens by liquid chromatography\u2010tandem mass spectrometry for the determination of cocaine, opioids, methadone, and amphetamines, and compared the analytical results from the four different matrices. The cases were divided in non\u2010exposure, low, and frequent exposure, based on maternal hair concentrations and segmental analysis by trimesters. For cocaine, 62 cases tested positive in hair, 9 in meconium, 6 in placenta and 7 in umbilical cord. In the case of opioids, 14 maternal hair cases were positive, 11 meconium and umbilical cord and 9 placenta samples. For methadone, 11 cases were positive in hair, 9 in meconium and 6 in placenta and umbilical cord. For amphetamines, 18 cases were positive according to maternal hair, but all meconium, placenta, and umbilical cord tested negative. Maternal hair was the most sensitive specimen to detect drug exposure during pregnancy. Meconium, placenta, and umbilical cord tested positive if hair concentrations showed frequent drug use during the whole pregnancy, especially during the third trimester. Meconium, placenta, and umbilical cord also tested positive for morphine and metabolites, if this drug was administered during labour and delivery. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.2087","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T18:02:57Z","timestamp":1473098577000},"page":"898-904","source":"Crossref","is-referenced-by-count":47,"title":["Bioanalysis for cocaine, opiates, methadone, and amphetamines exposure detection during pregnancy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3858-1280","authenticated-orcid":false,"given":"Marta","family":"Concheiro","sequence":"first","affiliation":[{"name":"John Jay College of Criminal Justice City University of New York  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Lendoiro","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Toxicolog\u00eda, Instituto de Ciencias Forenses Universidad de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9832-012X","authenticated-orcid":false,"given":"Ana","family":"de Castro","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Toxicolog\u00eda, Instituto de Ciencias Forenses Universidad de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"G\u00f3nzalez\u2010Colmenero","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neonatolog\u00eda Complejo Hospitalario Universitario de Vigo  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Concheiro\u2010Guisan","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neonatolog\u00eda Complejo Hospitalario Universitario de Vigo  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Pe\u00f1as\u2010Silva","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Ginecolog\u00eda y Obstetricia Complejo Hospitalario Universitario de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Macias\u2010Corti\u00f1a","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Ginecolog\u00eda y Obstetricia Complejo Hospitalario Universitario de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelines","family":"Cruz\u2010Landeira","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Toxicolog\u00eda, Instituto de Ciencias Forenses Universidad de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4233-1679","authenticated-orcid":false,"given":"Manuel","family":"L\u00f3pez\u2010Rivadulla","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Toxicolog\u00eda, Instituto de Ciencias Forenses Universidad de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/ijamh.2012.016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000052"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199009000-00008"},{"key":"e_1_2_7_5_1","first-page":"1","volume":"18","author":"Cruz Landeira A.","year":"2006","journal-title":"G\u00f3mez. 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