{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:21:59Z","timestamp":1762917719597,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T00:00:00Z","timestamp":1476316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Procedures for the extraction\u2010spectrophotometric determination of tris(2\u2010chloroethyl)amine, an alkylating agent known as a drug as well as a chemical warfare agent (nitrogen mustard HN\u20103), with 7 acid\u2010base indicators of a triphenylmethane lactone type, phthaleins, were developed. Representatives of phthaleins without an oxygen bridge (thymolphthalein, <jats:italic>o<\/jats:italic>\u2010cresolphthalein, naphtholphthalein) and with an oxygen bridge (fluorescein, 2',7'\u2010dichlorofluorescein, eosin B and eosin Y) were used. The methods were based on the formation of ion pair complexes. Chloroform was used as a non\u2010polar solvent for an extraction. The conditions to determine were optimized for the optimal pH of the buffer and the concentration of a phthalein as a reagent. The dependence on the reaction time in a water phase and the stoichiometry of extraction products were studied. The detection limits and the limits of the determination of separate procedures and conditional extraction constants were determined. Comparison with the spectrophotometric method of the group determination of alkyl halides and acyl halides using alkaline ethanol\u2010water solution of thymolphthalein, the so\u2010called T\u2010135 agent, was conducted. While studying the selectivity, the possible interference of bis(2\u2010chloroethyl)sulphide and 3 nitrogen mustards in the proposed procedures were verified. 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