{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:18:11Z","timestamp":1760404691091,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Gonadotropin\u2010releasing hormone (GnRH) is a 10\u2010residue peptide hormone that induces secretion of luteinizing hormone (LH) and follicle\u2010stimulating hormone into the blood from the pituitary gland. In males, LH acts on the testes to produce testosterone. The performance\u2010enhancing potential of testosterone makes administration of exogenous GnRH a concern in sports doping control. Detection of GnRH abuse is challenging owing to its rapid clearance from the body and its degradation in urine. Following recent investigations of GnRH abuse in racing greyhounds in New Zealand, we carried out a GnRH administration study in greyhounds in an attempt to identify GnRH metabolites that might provide more facile detection of GnRH abuse; little information is available on <jats:italic>in vivo<\/jats:italic> metabolites of exogenous GnRH in any species and none in dogs. We identified three C\u2010terminal GnRH metabolites in urine: GnRH 5\u201310, GnRH 6\u201310, and GnRH 7\u201310. These metabolites and intact GnRH, which was also detected in urine, were all excreted over a 1\u20133\u00a0h period after GnRH administration. Two of the GnRH metabolites \u2013 GnRH 5\u201310 and GnRH 6\u201310 \u2013 were more stable in urine than intact GnRH offering improved potential to detect GnRH administration. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.2164","type":"journal-article","created":{"date-parts":[[2017,1,14]],"date-time":"2017-01-14T07:53:09Z","timestamp":1484380389000},"page":"1499-1505","source":"Crossref","is-referenced-by-count":6,"title":["Identification of gonadotropin\u2010releasing hormone metabolites in greyhound urine"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8969-5192","authenticated-orcid":false,"given":"David","family":"Palmer","sequence":"first","affiliation":[{"name":"New Zealand Racing Laboratory Services Ltd  PO Box 19514, Avondale Auckland 1746 New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Rademaker","sequence":"additional","affiliation":[{"name":"New Zealand Racing Laboratory Services Ltd  PO Box 19514, Avondale Auckland 1746 New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Martin","sequence":"additional","affiliation":[{"name":"New Zealand Racing Laboratory Services Ltd  PO Box 19514, Avondale Auckland 1746 New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Hessell","sequence":"additional","affiliation":[{"name":"Racing Integrity Unit  Private Bag 17902, Greenlane Auckland 1546 New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Howitt","sequence":"additional","affiliation":[{"name":"New Zealand Racing Laboratory Services Ltd  PO Box 19514, Avondale Auckland 1746 New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-15-0113"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1999.tb02488.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1410257"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513599909167587"},{"key":"e_1_2_5_6_1","first-page":"153","article-title":"Clinical uses of gonadotropin\u2010releasing hormone analogues","volume":"144","author":"Casper R. 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