{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:23:16Z","timestamp":1762917796882,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Often in hair analysis, a small hair sample is available while the analysis of a multitude of structurally diverse substances with different concentration ranges is demanded. The analysis of the different substances often requires different sample preparation methods, increasing the amount of required hair sample. When segmental hair analysis is necessary, the amount of hair sample needed is further increased. Therefore, the required sample amount for a full analysis can quickly exceed what is available. To combat this problem, a method for the combined hair sample preparation using a single extraction procedure for analysis of ethyl glucuronide with liquid chromatography\u2010multistage fragmentation mass spectrometry\/multiple reaction monitoring (LC\u2013MS<jats:sup>3<\/jats:sup>\/MRM) and common drugs of abuse with LC\u2013MRM was developed. The combined sample preparation is achieved by separating ethyl glucuronide from the drugs of abuse into separate extracts by fractionation in the solid\u2010phase extraction step during sample clean\u2010up. A full validation for all substances for the parameters selectivity, linearity, limit of detection, limit of quantification, accuracy, precision, matrix effects, and recovery was successfully completed. The following drugs of abuse were included in the method: Amphetamine; methamphetamine; 3,4\u2010methylenedioxy\u2010N\u2010methylamphetamine (MDMA); 3,4\u2010methylenedioxyamphetamine (MDA); 3,4\u2010methylenedioxy\u2010N\u2010ethylamphetamine (MDE); morphine; 6\u2010monoacetylmorphine; codeine; acetylcodeine; cocaine; benzoylecgonine; norcocaine; cocaethylene; methadone; 2\u2010ethylidene\u20101,5\u2010dimethyl\u20103,3\u2010diphenylpyrrolidine (EDDP) and methylphenidate. In conclusion, as only 1 sample preparation is needed with 1 aliquot of hair, the presented sample preparation allows an optimal analysis of both ethyl glucuronide and of the drugs of abuse, even when the sample amount is a limiting factor.<\/jats:p>","DOI":"10.1002\/dta.2314","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T19:02:36Z","timestamp":1507575756000},"page":"701-710","source":"Crossref","is-referenced-by-count":8,"title":["Sample preparation method for the combined extraction of ethyl glucuronide and drugs of abuse in hair"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-9467","authenticated-orcid":false,"given":"Ulf","family":"Meier","sequence":"first","affiliation":[{"name":"Forensic Chemistry and Toxicology Institute of Forensic Medicine of the University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Briellmann","sequence":"additional","affiliation":[{"name":"Forensic Chemistry and Toxicology Institute of Forensic Medicine of the University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2742-0422","authenticated-orcid":false,"given":"Eva","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Forensic Chemistry and Toxicology Institute of Forensic Medicine of the University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Dussy","sequence":"additional","affiliation":[{"name":"Forensic Chemistry and Toxicology Institute of Forensic Medicine of the University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.02.019"},{"volume-title":"Analytical and Practical Aspects of Drug Testing in Hair","year":"2007","author":"Kintz P","key":"e_1_2_5_3_1"},{"volume-title":"Hair Analysis in Clinical and Forensic Toxicology","year":"2015","author":"Kintz P","key":"e_1_2_5_4_1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.10.007"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2013.10.008"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.6.769"},{"issue":"5","key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1515\/cclm-2013-0784","article-title":"Rapid extraction, identification and quantification of drugs of abuse in hair by immunoassay and ultra\u2010performance liquid chromatography tandem mass spectrometry","volume":"52","author":"Pichini S","year":"2014","journal-title":"cclm"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(93)90255-9"},{"issue":"2","key":"e_1_2_5_10_1","first-page":"83","article-title":"Recommendations for hair testing in forensic cases","volume":"145","author":"Society of Hair Testing","year":"2004","journal-title":"Forensic Sci Int"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.10.024"},{"key":"e_1_2_5_12_1","unstructured":"Schweizerische Gesellschaft f\u00fcr Rechtsmedizin.Bestimmung von Ethylglucuronid (EtG) in Haarproben.2014;http:\/\/www.sgrm.ch\/uploads\/media\/EtG_FINAL_2014.pdf. Accessed July 19 2016."},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1654"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2014.07.021"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2014.11.022"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2013.07.024"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2186"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/32.7.457"},{"issue":"3","key":"e_1_2_5_19_1","first-page":"185","article-title":"Anhang B zur Richtlinie der GTFCh zur Qualit\u00e4tssicherung bei forensisch\u2010toxikologischen Untersuchungen. Anforderungen and die Validierung von Analysemethoden","volume":"76","author":"Peters FT","year":"2009","journal-title":"Toxichem Krimtech"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2009.07.023"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2016.08.012"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.07.050"},{"key":"e_1_2_5_23_1","unstructured":"Society of Hair Testing.Consensus for the Use of Alcohol Markers in Hair for Assessment of both Abstinence and Chronic Excessive Alcohol Consumption.2016;http:\/\/www.soht.org\/index.php\/consensus. Accessed November 17 2016."},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.12.021"},{"issue":"1","key":"e_1_2_5_25_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.forsciint.2003.07.013","article-title":"Optimized conditions for simultaneous determination of opiates, cocaine and benzoylecgonine in hair samples by GC\u2013MS","volume":"138","author":"Romolo FS","year":"2003","journal-title":"Forensic Sci Int"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.01.044"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2014.05.055"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.10.041"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/13.5.250"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdta.2314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.2314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T10:17:52Z","timestamp":1760350672000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.2314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,27]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/dta.2314"],"URL":"https:\/\/doi.org\/10.1002\/dta.2314","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"type":"print","value":"1942-7603"},{"type":"electronic","value":"1942-7611"}],"subject":[],"published":{"date-parts":[[2017,11,27]]}}}