{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:41:27Z","timestamp":1790350887102,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In recent years, new drugs, commonly known as new psychoactive substances (NPS), appeared on the market, which include, among others, synthetic cannabinoids, cathinones, and tryptamine analogs of psilocin. The aim of this work was to develop and validate a new method for simultaneous screening and quantification of 31 NPS in oral fluid by ultra\u2010high\u2010performance liquid chromatography\u2010tandem mass spectrometry (UHPLC\u2013MS\/MS). The chosen target analytes represented different chemical and toxicological NPS classes, such as synthetic cathinones, piperazines, phenethylamines, synthetic cannabinoids, and their metabolites. The procedure involved a rapid sample preparation based on protein precipitation followed by clean\u2010up utilizing microextraction by packed sorbent (MEPS); the quantitative analysis was performed by UHPLC\u2013MS\/MS. The MEPS clean\u2010up, regardless of non\u2010quantitative recoveries for some analytes, provided an effective removal of interfering compounds, as demonstrated by reduced matrix effects found at different concentrations for all the analytes. The validation protocol, based on SWGTOX guidelines, demonstrated the suitability of the proposed method for quantitative analysis: linearity range ranged over 3 or 4 orders of magnitude; precision and accuracy tests gave RSD% values below 25%, and accuracy ranged from 85.9% to 107%, accomplishing SWGTOX requirements. Limits of detection (LODs) ranged between 0.005 ng\/mL and 0.850 ng\/mL and limits of quantification (LOQs) from 0.015 to 2.600 ng\/mL.<\/jats:p>","DOI":"10.1002\/dta.2330","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T17:52:40Z","timestamp":1509126760000},"page":"865-873","source":"Crossref","is-referenced-by-count":61,"title":["Analysis of new psychoactive substances in oral fluids by means of microextraction by packed sorbent followed by ultra\u2010high\u2010performance liquid chromatography\u2013tandem mass spectrometry"],"prefix":"10.1002","volume":"10","author":[{"given":"Rachele","family":"Rocchi","sequence":"first","affiliation":[{"name":"Faculty of Bioscience and Technology for Food, Agriculture and Environment University of Teramo  Teramo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Simeoni","sequence":"additional","affiliation":[{"name":"Faculty of Bioscience and Technology for Food, Agriculture and Environment University of Teramo  Teramo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Montesano","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Vannutelli","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Curini","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1130-5294","authenticated-orcid":false,"given":"Manuel","family":"Sergi","sequence":"additional","affiliation":[{"name":"Faculty of Bioscience and Technology for Food, Agriculture and Environment University of Teramo  Teramo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Compagnone","sequence":"additional","affiliation":[{"name":"Faculty of Bioscience and Technology for Food, Agriculture and Environment University of Teramo  Teramo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.12.049"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio-2015-0027"},{"key":"e_1_2_6_4_1","unstructured":"https:\/\/www.unodc.org\/LSS\/Announcement\/Details\/064a14a9-fbf1-4940-a184-74f9faab2254"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000240"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.12.047"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10337-011-2156-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.11.023"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkt080"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkt054"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(03)00889-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(04)00642-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200204000-00006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200404000-00020"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/29.7.724"},{"key":"e_1_2_6_16_1","first-page":"11","article-title":"Analysis of Drugs in Saliva","volume":"1","author":"Samyn N","year":"1999","journal-title":"Forensic Sci Rev."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.01.011"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.12.053"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-008-2135-4"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0379-0738(03)00098-7","article-title":"Simultaneous detection of some drugs of abuse in saliva samples by SPME technique","volume":"134","author":"Fucci N","year":"2003","journal-title":"Forensic Sci. 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