{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:40:21Z","timestamp":1779367221167,"version":"3.53.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,29]],"date-time":"2018-04-29T00:00:00Z","timestamp":1524960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["(2015\u201002836"],"award-info":[{"award-number":["(2015\u201002836"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the treatment of substance use disorder, regular laboratory\u2010based testing has the dual purpose of monitoring compliance with the prescribed medication and abstention from medically non\u2010motivated substances (ie, drug abuse screening). The principal specimen for testing is urine, but collection of urine has some disadvantages, for example being more time\u2010consuming and more intrusive compared to other matrices. There is also the risk of adulteration. This project compared exhaled breath and oral fluid as alternative matrices for drug abuse screening in patients with substance use disorder. All 51 subjects included in the study were enrolled at the Drug Addiction Emergency Unit in Stockholm. Exhaled breath, oral fluid, and urine samples were collected together with a self\u2010report. Of all 117 self\u2010reported drug intakes during the previous week, 72% were confirmed in urine, 73% in oral fluid and 39% in exhaled breath. In 31% of the subjects, additional substances other than those self\u2010reported were detected analytically. For substance abuse screening, urine had the highest detection rate for buprenorphine, cannabis, and benzodiazepines, while oral fluid had the highest detection rate for amphetamines and methadone. Exhaled breath showed the highest detection rate of all matrices for cocaine. To identify significant differences in detection rates between the matrices future studies with larger sampling sizes are needed. Both oral fluid and exhaled breath are viable alternative specimens to urine, depending on the circumstances and purpose of the testing.<\/jats:p>","DOI":"10.1002\/dta.2384","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T14:23:17Z","timestamp":1521987797000},"page":"27-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Drug abuse screening with exhaled breath and oral fluid in adults with substance use disorder"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-3745","authenticated-orcid":false,"given":"Michel","family":"Arvidsson","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Franck","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja\u2010Liisa","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3546-8872","authenticated-orcid":false,"given":"Olof","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.4.716"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2014.993336"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.03.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.92496"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2003.07.008"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"1","article-title":"Opioid guidelines in the management of chronic non\u2010cancer pain","volume":"9","author":"Trescot AM","year":"2006","journal-title":"Pain Physician."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/30.7.458"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/23.5.323"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.074237"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2004.248"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.153767"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18346.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/157341208786306180"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2005.02.028"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/32.6.393"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.11.023"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/34.5.233"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.06.035"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/anatox\/35.8.541"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465807082373"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419-016-0333-x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/7\/2\/026006"},{"issue":"9","key":"e_1_2_6_24_1","first-page":"1332","article-title":"Identification and quantitation of phosphatidylethanols in oral fluid by liquid chromatography\u2010tandem mass spectrometry","volume":"55","author":"Ullah S","year":"2017","journal-title":"Clin Chem Labor Med."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.01.032"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bks079"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.7903"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2014.09.003"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.368"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2009.12.006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.09.008"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/24.7.458"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac802055k"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/jam.1997.10.105"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2015.239285"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2009.0809"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdta.2384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.2384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:57:20Z","timestamp":1760363840000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.2384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,29]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/dta.2384"],"URL":"https:\/\/doi.org\/10.1002\/dta.2384","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"value":"1942-7603","type":"print"},{"value":"1942-7611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,29]]},"assertion":[{"value":"2018-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}