{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T23:10:33Z","timestamp":1760397033258,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T00:00:00Z","timestamp":1296691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rapid and highly sensitive method for the determination of acamprosate (ACM), in human plasma using ESI\u2010LC\u2010MS\/MS (electrospray ionization liquid chromatography tandem mass spectrometry) in negative ionization polarity in multiple reactions monitoring (MRM) mode was developed and validated. The procedure involves a simple protein precipitation step. Chromatographic separation was carried out on a Hypersil BDS C<jats:sub>18<\/jats:sub> column (150 mm \u00d7 4.6 mm, 5 \u00b5m) with an isocratic mobile phase and a total run time of 2.5 min. The standard calibration curves were linear within the range of 7.04\u2013702.20 ng\/mL for ACM (r \u2265 0.990). This study briefly describes the role of ion source design on matrix effects. ACM shows matrix effects in z\u2010spray ionization source design, whereas it has no matrix effects in orthogonal spray ion source design. This method was successfully applied to a pharmacokinetic study after oral administration of acamprosate 333 mg tablet in Indian healthy male volunteers. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.239","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T06:38:20Z","timestamp":1296715100000},"page":"735-742","source":"Crossref","is-referenced-by-count":4,"title":["A LC\u2010MS analysis of acamprosate from human plasma: pharmacokinetic application"],"prefix":"10.1002","volume":"3","author":[{"given":"Chinmoy","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrakant P.","family":"Shinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaswat S.","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,3]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"175","volume":"16","author":"Nalpas B.","year":"1990","journal-title":"Encephale."},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(87)80067-1"},{"key":"e_1_2_7_4_2","first-page":"1413","volume":"39","author":"Chabenat C.","year":"1989","journal-title":"Arzneimittel\u2010Forsch."},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)82333-6"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-001-1265-7"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181e18638"},{"key":"e_1_2_7_8_2","first-page":"631","volume":"59","author":"Xu F.","year":"2009","journal-title":"Arzneimittel\u2010Forsch."},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-009-1102-3"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dta.130"},{"volume-title":"Guidance for Industry, Bioanalytical Method Validation","year":"2001","author":"Food and Drug Administration","key":"e_1_2_7_11_2"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdta.239","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T22:42:56Z","timestamp":1760395376000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,3]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1002\/dta.239"],"URL":"https:\/\/doi.org\/10.1002\/dta.239","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"type":"print","value":"1942-7603"},{"type":"electronic","value":"1942-7611"}],"subject":[],"published":{"date-parts":[[2011,2,3]]}}}