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Four types of alcoholic beverages usually consumed in parties and bars were spiked with 5 distinct benzodiazepines (diazepam, alprazolam, bromazepam, clonazepam, and cloxazolam) simulating a drug\u2010facilitated crime occurrence. The direct PS\u2013MS analysis of the spiked beverages revealed a remarkable matrix effect with an unclear detection of protonated benzodiazepines. However, by the application of the LLE\u2013LTP using liquid nitrogen, a prompt and doubtless detection of such compounds was achieved. The quantification potential of the LLE\u2013LTP\/PS\u2013MS methodology was demonstrated by using beer as matrix, diazepam as target analyte and cloxazolam as an internal standard. Figures of merit (linearity, limit of detection, linear dynamic range, relative standard deviation, and recovery) were determined and adequate values were obtained. In conclusion, we demonstrated herein that the LLE\u2013LTP\/PS\u2013MS methodology has potential to be applied directly at the crime scene through of a portable mass spectrometer and a thermal container for the transport of liquid nitrogen.<\/jats:p>","DOI":"10.1002\/dta.2395","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T20:10:15Z","timestamp":1523909415000},"page":"1348-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Recognizing drug\u2010facilitated crimes: Detection and quantification of benzodiazepines in beverages using fast liquid\u2013liquid extraction with low temperature partitioning and paper spray mass spectrometry"],"prefix":"10.1002","volume":"10","author":[{"given":"Camila","family":"de Paula","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Ci\u00eancias Exatas Universidade Federal de Minas Gerais  Belo Horizonte 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