{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:04:45Z","timestamp":1787961885519,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In the context of post\u2010marketing surveillance supporting public\u2010health authorities to take evidence\u2010based decisions to fight the spread of poor\u2010quality medicines, the quality of antimalarial artemether\u2010lumefantrine (AL) medicines was assessed in the Democratic Republic of the Congo (DRC). A total of 150 samples of AL\u2010containing products was collected from private pharmaceutical outlets in 8 main cities: Goma, Kikwit, Kinshasa, Kisangani, Lubumbashi, Matadi, Mbandaka, and Mbuji\u2010Mayi. All drug samples were successively analyzed by visual inspection, thin\u2010layer chromatography (TLC), and high\u2010performance liquid chromatography (HPLC) following\n                    <jats:italic>The International Pharmacopoeia<\/jats:italic>\n                    . Of the 150 collected drug samples, 3 (2%) failed the visual inspection as they had shelf lives different from those of other samples with the same brand name. Four samples (2.7%) did not pass the TLC test as they contained only 1 or even none of the 2 declared active pharmaceutical ingredients (APIs). HPLC assays showed that 46 (30.7%) samples had artemether contents below 90% and 17 (11.3%) above 110% of the content claimed on the label. For lumefantrine, 32 (21.7%) samples had contents below 90%, and 8 (5.3%) had contents above 110%. This survey in DRC gives evidence that poor\u2010quality antimalarial medicines are widely present. Based on 3 detection techniques, the study shows the necessity to equip developing countries with modern techniques such as HPLC, which, if combined with affordable techniques like TLC, could provide a pertinent analytical strategy to combat drug counterfeiting and poor manufacturing.\n                  <\/jats:p>","DOI":"10.1002\/dta.2420","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T21:50:26Z","timestamp":1528840226000},"page":"1599-1606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quality of the antimalarial medicine artemether \u2013 lumefantrine in 8 cities of the Democratic Republic of the Congo"],"prefix":"10.1002","volume":"10","author":[{"given":"Jean\u2010Pierre","family":"Mufusama","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry University of W\u00fcrzburg  Germany"},{"name":"Facult\u00e9 des Sciences Pharmaceutiques Universit\u00e9 de Kinshasa  Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Ndjoko Ioset","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry University of W\u00fcrzburg  Germany"},{"name":"Facult\u00e9 des Sciences Universit\u00e9 de Lubumbashi  Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Feineis","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry University of W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Hoellein","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Food Chemistry University of W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-7278","authenticated-orcid":false,"given":"Ulrike","family":"Holzgrabe","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Food Chemistry University of W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-5935","authenticated-orcid":false,"given":"Gerhard","family":"Bringmann","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry University of W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO.World malaria report 2015.WHO Geneva 2015.http:\/\/apps.who.int\/iris\/bitstream\/10665\/200018\/1\/9789241565158_eng.pdf. 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