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The illicit market for these substances is characterized by the continuous introduction to the market of new analogs to evade legislation and to avoid detection. New screening and confirmation assays are therefore needed, mainly in forensic\/clinical samples. In the current development, a porous membrane\u2010protected, micro\u2010solid\u2010phase extraction (\u03bc\u2010SPE) has been developed for the assessment of several cathinones in urine. The \u03bc\u2010SPE device consisted of a cone\u2010shaped polypropylene (PP) porous membrane containing the adsorbent (molecularly imprinted polymers, MIPs, synthesized for the first time for this class of drugs). MIPs were prepared using ethylone and 3\u2010methylmethcathinone (3\u2010MMC) as templates, ethylene glycol dimethacrylate (EGDMA) as a functional monomer, divinylbenzene (DVB) as a cross\u2010linker, and 2,2\u00b4\u2010azobisisobutyronitrile (AIBN) as an initiator. The prepared ethylone\u2010based MIP and 3\u2010MMC\u2010based MIP have been fully characterized and evaluated as new selective adsorbents for \u03bc\u2010SPE. Cathinones separation\/determination was performed by high performance liquid chromatography\u2013tandem mass spectrometry (HPLC\u2013MS\/MS). Optimum loading conditions (pH\u00a05.0, loading for 4.0\u00a0minutes under orbital\u2010horizontal shaking at 200\u00a0rpm) and elution conditions [2.0\u00a0mL of 75:20:5 heptane\/2\u2010propanol\/ammonium hydroxide and ultrasounds assistance (37\u00a0kHz, 325\u00a0W) for 4.0\u00a0minutes] were found for ethylone\u2010based MIP. Validation (intra\u2010day and inter\u2010day precision and analytical recovery) showed RSD values lower than 9 and 10% for intra\u2010day and inter\u2010day precision, and within the 88%\u2013101% range for intra\u2010day and inter\u2010day analytical recovery.<\/jats:p>","DOI":"10.1002\/dta.2448","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T02:46:42Z","timestamp":1530499602000},"page":"33-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["HPLC\u2010MS\/MS combined with membrane\u2010protected molecularly imprinted polymer micro\u2010solid\u2010phase extraction for synthetic cathinones monitoring in urine"],"prefix":"10.1002","volume":"11","author":[{"given":"Juan","family":"S\u00e1nchez\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Group of Trace Elements, Spectroscopy, and Speciation (GETEE), Health Research Institute of Santiago de Compostela (IDIS), 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