{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:04:20Z","timestamp":1760403860101,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Detection of heroin use is an important task in clinical drug testing and can be best performed by using 6\u2010acetylmorphine as the target analyte. This study was performed to evaluate an on\u2010site test for 6\u2010acetylmorphine screening in urine with an assigned cut\u2010off limit at 10\u00a0ng\/mL. The reference method was a forensic accredited liquid chromatography\u2013tandem mass spectrometry method. The study confirmed that negative controls and negative authentic specimen resulted in negative readings. Low cross\u2010reactivity was recorded from other potential interfering opioids. Prepared standards and commercial calibrators demonstrated that the cutoff level of the test was lower than the assigned value and rather 2\u00a0ng\/mL. A study using authentic specimens from patients on substitution treatment with methadone, morphine, and buprenorphine confirmed that the real cut\u2010off level was 2\u00a0ng\/mL. Using this value as cutoff limit the sensitivity and specificity of the test was 100%.<\/jats:p>","DOI":"10.1002\/dta.2559","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T04:34:34Z","timestamp":1545280474000},"page":"536-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of an on\u2010site test device for the heroin metabolite 6\u2010acetylmorphine in urine"],"prefix":"10.1002","volume":"11","author":[{"given":"Fabian","family":"Picht","sequence":"first","affiliation":[{"name":"MVZ Labor Dessau GmbH  Dessau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3546-8872","authenticated-orcid":false,"given":"Olof","family":"Beck","sequence":"additional","affiliation":[{"name":"MVZ Labor Dessau GmbH  Dessau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"B\u00f6ttcher","sequence":"additional","affiliation":[{"name":"MVZ Labor Dessau GmbH  Dessau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550887.2010.509277"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2010.02373.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/15.1.1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/17.6.327"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1486"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/31.1.1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/28.6.489"},{"key":"e_1_2_5_9_1","first-page":"414","article-title":"Clinical and forensic diagnosis of very recent heroin intake by 6\u2010acetylmorphine immunoassay test and LC\u2010MS\/MS analysis in urine and blood","volume":"45","author":"Borriello R","year":"2015","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkv090"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181e61923"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2011.07.008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2016.11.003"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2014.939995"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/26.4.233"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/29.3.201"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/20.7.541"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181a45e78"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdta.2559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.2559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dta.2559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.2559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:19:37Z","timestamp":1760386777000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.2559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,6]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/dta.2559"],"URL":"https:\/\/doi.org\/10.1002\/dta.2559","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"type":"print","value":"1942-7603"},{"type":"electronic","value":"1942-7611"}],"subject":[],"published":{"date-parts":[[2019,1,6]]},"assertion":[{"value":"2018-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}