{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:27:28Z","timestamp":1790800048028,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>According to French law, the roadside testing for drugs of abuse (DOA) should be performed in oral fluid (OF) using an immunological screening kit. If the screening is positive, confirmation has to be done in OF collected by a special swab, called the FLOQSwab\u2122 (FS). Unlike other sampling kits, this device was not designed to collect OF since it does not contain an elution buffer. An analytical method was developed for the simultaneous detection of 10 DOA under control in France: tetrahydrocannabinol (THC) at 1\u00a0ng\/mL, and cocaine, benzoylecgonine (BZE), morphine, 6\u2010monoacetylmorphine (6\u2010MAM), amphetamine, methamphetamine, 3,4\u2010methylenedioxy\u2010<jats:italic>N<\/jats:italic>\u2010ethylamphetamine (MDEA), 3,4\u2010methylenedioxyamphetamine (MDA), and 3,4\u2010methylenedioxy\u2010<jats:italic>N<\/jats:italic>\u2010methylamphetamine (MDMA) at 10\u00a0ng\/mL. Samples were eluted using the Quantisal<jats:sup>\u00ae<\/jats:sup> buffer and extracted by liquid\u2013liquid extraction for THC and by solid\u2010phase extraction for the remaining analytes. Analyses were performed by ultra\u2010high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC\u2013MS\/MS). The validated method made it possible to detect the concentrations required by law and was successfully applied to samples from drivers who screened positive. The main limitations of this kit are the large variability of the collected OF volume and the poor stability of DOA in OF, requiring the use of a conservation buffer.<\/jats:p>","DOI":"10.1002\/dta.2563","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T11:04:29Z","timestamp":1545995069000},"page":"824-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Development and validation of a liquid chromatography\u2010tandem mass spectrometry method for simultaneous detection of 10 illicit drugs in oral fluid collected with FLOQSwabs\u2122 and application to real samples"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-2306","authenticated-orcid":false,"given":"Nicolas","family":"Fabresse","sequence":"first","affiliation":[{"name":"Plateforme MasSpecLab, U\u2010INSERM 1173, UFR Simone Veil Universit\u00e9 de Versailles Saint\u2010Quentin  2 avenue de la source de la Bi\u00e8vre 78180 Montigny le Bretonneux France"},{"name":"Laboratoire de Pharmacologie et de Toxicologie H\u00f4pital Raymond Poincar\u00e9, AP\u2010HP  104 Boulevard Raymond Poincar\u00e9 92380 Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Aouad","sequence":"additional","affiliation":[{"name":"Plateforme MasSpecLab, U\u2010INSERM 1173, UFR Simone Veil Universit\u00e9 de Versailles Saint\u2010Quentin  2 avenue de la source de la Bi\u00e8vre 78180 Montigny le Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Knapp","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie et de Toxicologie H\u00f4pital Raymond Poincar\u00e9, AP\u2010HP  104 Boulevard Raymond Poincar\u00e9 92380 Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Mayer","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie et de Toxicologie H\u00f4pital Raymond Poincar\u00e9, AP\u2010HP  104 Boulevard Raymond Poincar\u00e9 92380 Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Etting","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie et de Toxicologie H\u00f4pital Raymond Poincar\u00e9, AP\u2010HP  104 Boulevard Raymond Poincar\u00e9 92380 Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-5342","authenticated-orcid":false,"given":"Islam Amine","family":"Larabi","sequence":"additional","affiliation":[{"name":"Plateforme MasSpecLab, U\u2010INSERM 1173, UFR Simone Veil Universit\u00e9 de Versailles Saint\u2010Quentin  2 avenue de la source de la Bi\u00e8vre 78180 Montigny le Bretonneux France"},{"name":"Laboratoire de Pharmacologie et de Toxicologie H\u00f4pital Raymond Poincar\u00e9, AP\u2010HP  104 Boulevard Raymond Poincar\u00e9 92380 Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Plateforme MasSpecLab, U\u2010INSERM 1173, UFR Simone Veil Universit\u00e9 de Versailles Saint\u2010Quentin  2 avenue de la source de la Bi\u00e8vre 78180 Montigny le Bretonneux France"},{"name":"Laboratoire de Pharmacologie et de Toxicologie H\u00f4pital Raymond Poincar\u00e9, AP\u2010HP  104 Boulevard Raymond Poincar\u00e9 92380 Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament et des produits de sant\u00e9.Stup\u00e9fiants et psychotropes.http:\/\/ansm.sante.fr\/Produits\u2010de\u2010sante\/Stupefiants\u2010et\u2010psychotropes. 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