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Samples were solid\u2010phase extracted and extracts analyzed by liquid chromatography\u2013tandem mass spectrometry using, for the first time in the illicit drug field, a stationary phase that combines reversed\u2010phase and weak cation\u2010exchange functionalities. The overall method performance was satisfactory, with limits of detection below 1\u00a0ng\/L, relative standard deviations below 21%, and percentages of recovery between 93% and 121%. Analysis of 24\u2010hour composite raw wastewater samples collected in Santiago de Compostela (Spain) and Brasilia (Brazil) highlighted benzoylecgonine as the compound showing the highest population\u2010normalized mass loads (300\u20131000\u00a0mg\/day\/1000 inhabitants). In Brasilia, cocaine and levamisole loads underwent an upsurge on Sunday, indicating a high consumption, and likely a direct disposal, of cocaine powder on this day. Conversely, the pyrolytic product resulting from the smoke of crack, anhydroecgonine methyl ester, and its metabolite anhydroecgonine were relatively stable over the four days, agreeing with a non\u2010recreational\u2010associated use of crack.<\/jats:p>","DOI":"10.1002\/dta.2590","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:15:06Z","timestamp":1553040906000},"page":"1018-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Profiling cocaine residues and pyrolytic products in wastewater by mixed\u2010mode liquid chromatography\u2013tandem mass spectrometry"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-8380","authenticated-orcid":false,"given":"Iria","family":"Gonz\u00e1lez\u2010Mari\u00f1o","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Sciences, IIAA \u2013 Institute for Food Analysis and Research Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Est\u00e9vez\u2010Danta","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Sciences, IIAA \u2013 Institute for Food Analysis and Research Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Rodil","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Sciences, IIAA \u2013 Institute for Food Analysis and Research Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katyeny Manuela","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Institute of Chemistry University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-8492","authenticated-orcid":false,"given":"Fernando Fabriz","family":"Sodr\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Chemistry University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Cela","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Sciences, IIAA \u2013 Institute for Food Analysis and Research Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Benito","family":"Quintana","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Nutrition and Food Sciences, IIAA \u2013 Institute for Food Analysis and Research Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.01.274"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.03.175"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.12.269"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.05.262"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.02.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.05.207"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.05.078"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.05.128"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2013.11.094"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12570"},{"key":"e_1_2_7_12_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).European drug report 2018: trends and developments. 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