{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:10:52Z","timestamp":1760415052044,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,2,21]],"date-time":"2011-02-21T00:00:00Z","timestamp":1298246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>This is the first report on the use of visible spectrophotometry for the determination of bupropion hydrochloride (BUPH), a second\u2010generation antidepressant, in pharmaceuticals. Two sensitive, selective, and cost\u2010effective spectrophotometric methods are described. The first method (method A) is based on the formation of yellow\u2010coloured ion\u2010pair complex between the BUPH and methyl orange (MO) at pH 3.80 \u00b1 0.10 which was extracted into dichloromethane and the absorbance measured at 425 nm. The second method (method B) is based on the breaking of the yellow BUPH\u2010MO ion\u2010pair complex in acid medium followed by the measurement of the red\u2010pink colour at 520 nm. Beer's Law is obeyed over the concentration ranges of 1.00\u201312.0 and 0.48\u20137.20 \u00b5g ml<jats:sup>\u22121<\/jats:sup> BUPH for method A and method B, respectively. The molar absorptivities are calculated to be 2.18 \u00d7 10<jats:sup>4<\/jats:sup> and 3.79 \u00d7 10<jats:sup>4<\/jats:sup> l mol<jats:sup>\u22121<\/jats:sup> cm<jats:sup>\u22121<\/jats:sup> for method A and method B, respectively, and the corresponding Sandell sensitivity values are 0.0127 and 0.0073 \u00b5g cm<jats:sup>\u22122<\/jats:sup>. The limits of detection and quantification have also been reported. The proposed methods were applied successfully to the determination of BUPH in pure drug and commercial tablets. The accuracy and reliability of the proposed methods were further ascertained by recovery studies <jats:bold><jats:italic>via<\/jats:italic><\/jats:bold> standard addition technique. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.266","type":"journal-article","created":{"date-parts":[[2011,2,21]],"date-time":"2011-02-21T03:06:31Z","timestamp":1298257591000},"page":"486-492","source":"Crossref","is-referenced-by-count":0,"title":["Application of ion\u2010pair complexation reaction for the spectrophotometric determination of bupropion hydrochloride in pharmaceuticals"],"prefix":"10.1002","volume":"4","author":[{"given":"Kanakapura","family":"Basavaiah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer A. 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