{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:59:36Z","timestamp":1778795976567,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Up to 25% of hospitalized patients in a psychiatric department exhibit troubles linked to cannabis use. Weaning patients with psychiatric disorders off drugs of abuse requires specific care to improve their clinical outcome. The present study aims to develop a predictive model of urinary excretion of creatinine\u2010normalized cannabinoids (U<jats:sub>CNC<\/jats:sub>) and to determine U<jats:sub>CNC<\/jats:sub> thresholds corresponding to the widely used cut\u2010offs of 20\u00a0ng\/mL and 50\u00a0ng\/mL for cannabinoids. One hundred thirty\u2010two patients with 452 urine samples were included between 2013 and 2017. Urinary cannabinoids and U<jats:sub>CNC<\/jats:sub> elimination curves were computed for each patient. Using a mono\u2010exponential mixed effect model with 88 samples from 26 subjects exhibiting at least 3 decreasing U<jats:sub>CNC<\/jats:sub> in a row, the average calculated elimination rate constant was 0.0108\u00a0\u00b1\u00a00.0026\u00a0h<jats:sup>\u22121<\/jats:sup>, corresponding to a mean elimination half\u2010life of 64\u00a0\u00b1\u00a012\u00a0hours. The use of U<jats:sub>CNC<\/jats:sub> is of particular interest because of a high inter\u2010 and intra\u2010individual variability of urinary creatinine concentration (from 0.06 to 3.81\u00a0mg\/mL). Moreover, U<jats:sub>CNC<\/jats:sub> allows for the detection of diluted or concentrated urine specimens that may lead to false positive (FP) or false negative (FN) results. Receiver operator characteristic (ROC) curves were used to assess U<jats:sub>CNC<\/jats:sub> thresholds of 32.4 and 124.7\u00a0ng\/mg that provide a strong discrimination between positive and negative samples for cannabinoids cut\u2010offs of 20 and 50\u00a0ng\/mL respectively. The developed model and the defined U<jats:sub>CNC<\/jats:sub> thresholds allowed for the accurate prediction of the time needed to reach a negative U<jats:sub>CNC<\/jats:sub> result that could be used by clinicians to optimize clinical care.<\/jats:p>","DOI":"10.1002\/dta.2672","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T17:33:05Z","timestamp":1562002385000},"page":"1453-1459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interest of adjusting urine cannabinoids to creatinine level to monitor cannabis cessation therapy in heavy smokers with psychiatric disorders"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8730-284X","authenticated-orcid":false,"given":"Thomas","family":"Duflot","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacokinetics, Toxicology and Pharmacogenomics Rouen University Hospital  76000 Rouen France"},{"name":"Normandie Univ, UNIROUEN, INSERM U1096, FHU REMOD\u2010VHF  76000 Rouen France"},{"name":"Department of Pharmacology Rouen University Hospital  76000 Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Vasse","sequence":"additional","affiliation":[{"name":"Rouvray Psychiatric Hospital  F76300 Sotteville\u2010L\u00e8s\u2010Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Guillerme","sequence":"additional","affiliation":[{"name":"Department of General Biochemistry Rouen University Hospital  Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lien","family":"Schrapp","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Toxicology and Pharmacogenomics Rouen University Hospital  76000 Rouen 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France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Protais","sequence":"additional","affiliation":[{"name":"Rouvray Psychiatric Hospital  F76300 Sotteville\u2010L\u00e8s\u2010Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Guillin","sequence":"additional","affiliation":[{"name":"Rouvray Psychiatric Hospital  F76300 Sotteville\u2010L\u00e8s\u2010Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Goetz","sequence":"additional","affiliation":[{"name":"Rouvray Psychiatric Hospital  F76300 Sotteville\u2010L\u00e8s\u2010Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Lamoureux","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Toxicology and Pharmacogenomics Rouen University Hospital  76000 Rouen France"},{"name":"Normandie Univ, UNIROUEN, INSERM U1096, FHU REMOD\u2010VHF  76000 Rouen France"},{"name":"Department of Pharmacology Rouen University Hospital  76000 Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"United Nations Office on drugs and crime World Drug Report2014(United Nations publication Sales No. E.14.XI.7)."},{"key":"e_1_2_8_3_1","unstructured":"United Nations Office on drugs and crime World Drug Report2013(United Nations publication Sales No. E.13.XI.6)."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp031"},{"issue":"17","key":"e_1_2_8_5_1","first-page":"30265","article-title":"A method to achieve extended cannabis abstinence in cannabis dependent patients with schizophrenia and non\u2010psychiatric controls","volume":"9964","author":"Rabin RA","year":"2017","journal-title":"Schizophr 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