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Synthetic cannabinoid receptor agonists (SCRAs), colloquially known as \u201cspice\u201d, are infused into papers and are of particular concern in a prison setting where they are commonly vaped. Methods for the qualitative and quantitative analysis of SCRA infused papers, including impurity profiling, were developed using gas chromatography\u2013mass spectrometry (GC\u2013MS) with qualitative confirmation by ultra high pressure liquid chromatography with photodiode array and quadrupole time of flight mass spectrometry detection (UPLC\u2010PDA\u2010QToF\u2010MS) and applied to 354 individual seized paper samples originating from 168 seizures from three Scottish prisons. Of these samples, 41% (146 samples from 101 seizures) contained at least one SCRA and multiple SCRAs were detected on 23% of these papers. Concentrations ranged from &lt; 0.05\u20131.17 mg\/cm<jats:sup>2<\/jats:sup> paper, representing the first reported quantitative data for SCRA infused papers. An evolution in the SCRAs detected was demonstrated; 5F\u2010MDMB\u2010PINACA (5F\u2010ADB) predominated until late 2018, after which time 5F\u2010MDMB\u2010PICA and 4F\u2010MDMB\u2010BINACA became increasingly more prevalent, followed by the arrival of MDMB\u20104en\u2010PINACA in June 2019. Concentration mapping data from two seized paper samples demonstrated that SCRA concentrations across larger papers were highly variable (0.47\u20132.38 mg\/cm<jats:sup>2<\/jats:sup> paper) making consistent dosing by users, and representative sampling by laboratory analysts, difficult. Near real\u2010time qualitative and quantitative information on SCRAs circulating in prisons acts as an early warning system for SCRAs emerging on the wider illicit market, inform the methods used to detect them and limit supply, and provide information to support harm reduction measures.<\/jats:p>","DOI":"10.1002\/dta.2767","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T12:21:28Z","timestamp":1579090888000},"page":"538-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Detection and quantitation of synthetic cannabinoid receptor agonists in infused papers from prisons in a constantly evolving illicit market"],"prefix":"10.1002","volume":"12","author":[{"given":"Caitlyn","family":"Norman","sequence":"first","affiliation":[{"name":"Forensic Drug Research Group, Centre for Anatomy and Human Identification, School of Science and Engineering University of Dundee  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Walker","sequence":"additional","affiliation":[{"name":"Public Protection Unit, Scottish Prison Service  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"McKirdy","sequence":"additional","affiliation":[{"name":"Public Protection Unit, Scottish Prison Service  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciara","family":"McDonald","sequence":"additional","affiliation":[{"name":"Forensic Drug Research Group, Centre for Anatomy and Human Identification, School of Science and Engineering University of Dundee  UK"},{"name":"Department of Pure and Applied Chemistry University of Strathclyde  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, School of Life Sciences University of Dundee  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lysbeth H.","family":"Antonides","sequence":"additional","affiliation":[{"name":"Forensic Drug Research Group, Centre for Anatomy and Human Identification, School of Science and Engineering University of Dundee  UK"},{"name":"Leverhulme Research Centre for Forensic Science University of Dundee  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-7754","authenticated-orcid":false,"given":"Oliver B.","family":"Sutcliffe","sequence":"additional","affiliation":[{"name":"Division of Chemistry and Environmental Science Manchester Metropolitan University  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-0887","authenticated-orcid":false,"given":"Niamh","family":"Nic Da\u00e9id","sequence":"additional","affiliation":[{"name":"Forensic Drug Research Group, Centre for Anatomy and Human Identification, School of Science and Engineering University of Dundee  UK"},{"name":"Leverhulme Research Centre for Forensic Science University of Dundee  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7244-5779","authenticated-orcid":false,"given":"Craig","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Forensic Drug Research Group, Centre for Anatomy and Human Identification, School of Science and Engineering University of Dundee  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"HM Prison and Probation Service.Prison drugs strategy. 2019.https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/792125\/prison-drugs-strategy.pdfAccessed 11 September 2019."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2016.10.003"},{"key":"e_1_2_8_4_1","unstructured":"DjemilH.How to get drugs out of prisons. 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