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In this study, seven commercial surface\u2010enhanced Raman spectroscopy (SERS) substrates A\u2013G were compared for the analysis of cocaine. These substrates were compared using scanning electron microscopy to study the surface structure and Raman spectroscopy and to determine if there was any enhancement of the cocaine bands. Substrate B provided the best enhancement of known cocaine vibrational bands, allowing the detection down to concentrations of 1 ng\/mL in standards and 10 ng\/mL extracted from the oral fluid. The results showed that SERS is an ideal method for future rapid onsite analysis of illicit drugs in oral fluid. Commercial SERS substrates were compared for the analysis of cocaine. Substrate B provided the best result and was further tested with lower concentrations and extracts from the oral fluid. The application to oral fluid testing could prove useful for future onsite analysis.<\/jats:p>","DOI":"10.1002\/dta.2894","type":"journal-article","created":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T23:01:20Z","timestamp":1593990080000},"page":"944-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of commercial surface\u2010enhanced Raman spectroscopy substrates for the analysis of cocaine"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1619-1636","authenticated-orcid":false,"given":"Rhiannon","family":"Alder","sequence":"first","affiliation":[{"name":"Centre for Forensic Science University of Technology Sydney  Sydney NSW Australia"},{"name":"IDEAL ARC Research Hub University of Technology Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Xiao","sequence":"additional","affiliation":[{"name":"Centre for Forensic Science University of Technology Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6238-3612","authenticated-orcid":false,"given":"Shanlin","family":"Fu","sequence":"additional","affiliation":[{"name":"Centre for Forensic Science University of Technology Sydney  Sydney NSW Australia"},{"name":"IDEAL ARC Research Hub University of Technology Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Australian Burden of Disease Study: Impact and Causes of Illness and Death in Australia 2011","author":"Australian Institute of Health and Welfare","year":"2016"},{"key":"e_1_2_7_3_1","volume-title":"Impact of Alcohol and Illicit Drug Use on the Burden of Disease and Injury in Australia: Australian Burden of Disease Study 2011","author":"Australian Institute of Health and Welfare","year":"2018"},{"issue":"152","key":"e_1_2_7_4_1","article-title":"Dopamine signaling in reward\u2010related behaviors","volume":"7","author":"Baik JH","year":"2013","journal-title":"Frontiers in Neural Circuits"},{"key":"e_1_2_7_5_1","volume-title":"Drugs & Drug Abuse","author":"Brands B","year":"1998"},{"key":"e_1_2_7_6_1","volume-title":"Goodman & Gilman's the pharmacological basis of therapeutics","author":"Brunton L","year":"2011"},{"key":"e_1_2_7_7_1","volume-title":"Illicit Drug Data Report 2017\u201318","author":"Australian Criminal Intelligence Commission","year":"2019"},{"key":"e_1_2_7_8_1","volume-title":"Primer of Drug Action","author":"Julien RM","year":"2010"},{"key":"e_1_2_7_9_1","volume-title":"Treatment Options and Legal Penalties","author":"Campbell A","year":"2001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12691"},{"key":"e_1_2_7_11_1","unstructured":"Australian Criminal Intelligence Commission.National Wastewater Drug Monitoring Program\u2010 Report 6. 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