{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:05:54Z","timestamp":1773842754712,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T00:00:00Z","timestamp":1304640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>Due to its stimulatory effects on the central nervous system, and its structural similarity to banned stimulants such as ephedrine and methamphetamine, pseudoephedrine (PSE) at high doses is considered as an ergogenic aid for boosting athletic performance. However, the status of PSE in the International Standard of the Prohibited List as established under the World Anti\u2010Doping Code has changed over the years, being prohibited until 2003 at a urinary cut\u2010off value of 25 \u00b5g\/ml, and then subsequently removed from the Prohibited List during the period 2004\u20132009. The re\u2010consideration of this position by the World Anti\u2010Doping Agency (WADA) List Expert Group has led to the reintroduction of PSE in the Prohibited List in 2010. In this manuscript, we present the results of two WADA\u2010sponsored clinical studies on the urinary excretion of PSE and its metabolite cathine (CATH) following the oral administration of different PSE formulations to healthy individuals at therapeutic regimes. On this basis, the current analytical urinary threshold for the detection of PSE as a doping agent in sport has been conservatively established at 150 \u00b5g\/ml Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.291","type":"journal-article","created":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T03:14:32Z","timestamp":1304651672000},"page":"320-329","source":"Crossref","is-referenced-by-count":14,"title":["Determination of urinary concentrations of pseudoephedrine and cathine after therapeutic administration of pseudoephedrine\u2010containing medications to healthy subjects: implications for doping control analysis of these stimulants banned in sport"],"prefix":"10.1002","volume":"4","author":[{"given":"Osquel","family":"Barroso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Goudreault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel\u2010l\u00ed","family":"Carb\u00f3 Ban\u00fas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Ayotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Mazzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Boghosian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Rabin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.124523"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jaoac\/87.1.1","article-title":"Determination of ephedrine alkaloids in botanicals and dietary supplements by HPLC\u2010UV: collaborative study","volume":"87","author":"Roman M. 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