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Many prisons use benchtop ion mobility spectroscopy (IMS) instruments to screen mail and seized materials for the presence of SCRAs and other controlled substances. The selectivity and sensitivity of Rapiscan Itemiser<jats:sup>\u00ae<\/jats:sup> 3E and Itemiser<jats:sup>\u00ae<\/jats:sup> 4DN Ion Trap Mobility Spectroscopy\u2122 (ITMS\u2122) systems were evaluated using 21 SCRA reference standards. Some differences in the SCRA reduced mobility (<jats:italic>K<\/jats:italic><jats:sub>0<\/jats:sub>) values were observed between this study and those reported previously using IMS detection systems, particularly for cumyl and quinolinyl SCRAs (e.g., 5F\u2010PB\u201022, Cumyl\u20104CN\u2010BINACA, and 5F\u2010Cumyl\u2010PEGACLONE), although this was found to have little effect at an operational level. Operational reliability of the systems was evaluated by analyzing 392 paper and card samples with known drug content. ITMS\u2122 system results (e.g., detect or nondetect) were in agreement with gas chromatography\u2013mass spectrometry (GC\u2013MS) analysis in up to 95% of samples tested. Overall, this study found the ITMS\u2122 systems tested to be effective instruments when deployed for the rapid detection of SCRA\u2010infused papers. Used effectively and with up\u2010to\u2010date substance libraries, they will help reduce the supply of SCRAs into prisons and identify emerging threats as they arise. Several emerging SCRAs (5F\u2010MPP\u2010PICA, 5F\u2010EMB\u2010PICA, and 4F\u2010MDMB\u2010BICA) were detected for the first time in Scottish prisons between May and August 2020 as a result of routine monitoring, and all were detected using the ITMS\u2122 systems tested.<\/jats:p>","DOI":"10.1002\/dta.2945","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T11:49:49Z","timestamp":1602762589000},"page":"644-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Large\u2010scale evaluation of ion mobility spectrometry for the rapid detection of synthetic cannabinoid receptor agonists in infused papers in prisons"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-0367","authenticated-orcid":false,"given":"Caitlyn","family":"Norman","sequence":"first","affiliation":[{"name":"Leverhulme Research Centre for Forensic Science, School of Science and Engineering University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"McKirdy","sequence":"additional","affiliation":[{"name":"HMP Inverness Scottish Prison Service  Inverness UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Walker","sequence":"additional","affiliation":[{"name":"Public Protection Unit Scottish Prison Service  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Dugard","sequence":"additional","affiliation":[{"name":"Leverhulme Research Centre for Forensic Science, School of Science and Engineering University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-0887","authenticated-orcid":false,"given":"Niamh","family":"NicDa\u00e9id","sequence":"additional","affiliation":[{"name":"Leverhulme Research Centre for Forensic Science, School of Science and Engineering University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7244-5779","authenticated-orcid":false,"given":"Craig","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Leverhulme Research Centre for Forensic Science, School of Science and Engineering University of Dundee  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09687637.2016.1153604"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2016.10.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706406"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2018_143"},{"issue":"321","key":"e_1_2_7_6_1","first-page":"1","article-title":"Enantiospecific synthesis, chiral separation, and biological activity of four indazole\u20103\u2010carboxamide\u2010type synthetic cannabinoid receptor agonists and their detection in seized drug samples","volume":"7","author":"Antonides LH","year":"2019","journal-title":"Front Chem"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2688"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2607"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.246983"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2767"},{"key":"e_1_2_7_11_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).New Psychoactive Substances in Europe. 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