{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:11:02Z","timestamp":1772691062867,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0800903"],"award-info":[{"award-number":["2016YFC0800903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Performing fast qualitative identification of seized illegal drugs by Raman spectroscopy is challenging due to fluorescence interference as well as chemical complexity. Spectrometers with 785\u2010nm excitation, 1,064\u2010nm excitation, and sequentially shifted excitation (SSE) were compared for their effect on fluorescence reduction. The characteristic peaks method, which is independent of cutting agents, was tested as a new strategy to broaden the application of the Raman technique. The suitability of the characteristic peaks method was fully examined by analyzing a large amount of seized illegal drugs, including 72 methamphetamine hydrochloride (concentration range of 13.9%\u201399.4%), 68 ketamine hydrochloride (17.7%\u201399.8%), 176 heroin hydrochloride (5.2%\u201379.5%), 51 cocaine hydrochloride (21.1%\u201394.5%), and 33 cocaine base (30.9%\u201392.5%) samples. The results showed that seized methamphetamine, ketamine, and cocaine samples had no or little fluorescence. Hence, in regard to detection of these samples, the advantage of using 1,064\u2010nm excitation and SSE compared with 785\u2010nm excitation was quite limited. Regarding the heroin samples, a significant improvement of the \u201chigh\u201d confident positive detected rate was evident for 1,064 nm excitation (60.8%) and SSE (61.4%), compared with 785\u2010nm excitation (13.1%). However, it was also seen that even if 1,064\u2010nm excitation and SSE were applied, the fluorescence of heroin samples was still unable to be fully overcome. By using the characteristic peaks method, low LOD results of 5%\u201320% were acquired for 40 types of drug mixtures, and lower LODs were obtained for the 60% of the drug mixtures compared with library searching method. Raman spectroscopy in conjunction with the characteristic peaks method was shown to be fast, simple, accurate, and sensitive in the qualitative analysis of seized drug samples.<\/jats:p>","DOI":"10.1002\/dta.2963","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T13:51:08Z","timestamp":1604411468000},"page":"720-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["New qualitative analysis strategy for illicit drugs using Raman spectroscopy and characteristic peaks method"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-3489","authenticated-orcid":false,"given":"Cui\u2010Mei","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Drug Monitoring and Control Drug Intelligence and Forensic Center, Ministry of Public Security  Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Yuan","family":"He","sequence":"additional","affiliation":[{"name":"College of Investigation People's Public Security University of China  Beijing 100038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Investigation People's Public Security University of China  Beijing 100038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Dong","family":"Hua","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug Monitoring and Control Drug Intelligence and Forensic Center, Ministry of Public Security  Beijing 100193 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Office of China National Narcotics Control Commission.Annual report on drug control in China Beijing 2019."},{"key":"e_1_2_6_3_1","unstructured":"United Nations Office on Drugs and Crime (UNODC).World drug report 2019. 2019.https:\/\/wdr.unodc.org\/wdr2019\/. Accessed July 2019."},{"key":"e_1_2_6_4_1","unstructured":"United Nations Office on Drugs and Crime (UNODC).Recommended methods for the identification and analysis of amphetamine methamphetamine and their ring\u2010substituted analogues in seized materials.2006."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2132"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2030"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003702816638305"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739149.2012.686356"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5AN02326B"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556-4029.2010.01336.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.169"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2010.11.027"},{"issue":"11","key":"e_1_2_6_13_1","first-page":"3395","article-title":"Application of Raman spectroscopy in rapid detection of new\u2010type drugs","volume":"38","author":"Sui CH","year":"2018","journal-title":"Spectrosc Spec Anal"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.4864"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1366\/12-06852"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.2352"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2017.01.027"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003702816662621"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2015.01.021"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2016.07.129"},{"issue":"5","key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1520\/JFS12031J","article-title":"Identifications and quantitative measurements of narcotics in solid mixtures using near\u2010IR Raman spectroscopy and multivariate analysis","volume":"44","author":"Ryder AG","year":"2008","journal-title":"J Forensic Sci"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA05847D"},{"key":"e_1_2_6_23_1","unstructured":"The Japanese Pharmacopoeia Pharmaceutical and Medical Device Regulatory Science Society of Japan. 6th Ed.2011. p 53."},{"issue":"5","key":"e_1_2_6_24_1","first-page":"1439","article-title":"Rapid qualitative analysis of 13 precursor chemicals by Fourier transform infrared spectroscopy","volume":"39","author":"Liu CM","year":"2019","journal-title":"Spectrosc Spec Anal"},{"issue":"7","key":"e_1_2_6_25_1","first-page":"2136","article-title":"Rapid qualitative analysis of methamphetamine, ketamine, heroin, and cocaine by Fourier transform infrared spectroscopy","volume":"39","author":"Liu CM","year":"2019","journal-title":"Spectrosc Spec Anal"}],"container-title":["Drug Testing and Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.2963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dta.2963","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dta.2963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:07:22Z","timestamp":1760400442000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/dta.2963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/dta.2963"],"URL":"https:\/\/doi.org\/10.1002\/dta.2963","archive":["Portico"],"relation":{},"ISSN":["1942-7603","1942-7611"],"issn-type":[{"value":"1942-7603","type":"print"},{"value":"1942-7611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,10]]},"assertion":[{"value":"2020-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}