{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:03:01Z","timestamp":1768694581863,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001962","name":"World Anti-Doping Agency","doi-asserted-by":"publisher","award":["10D03AR"],"award-info":[{"award-number":["10D03AR"]}],"id":[{"id":"10.13039\/501100001962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001962","name":"World Anti-Doping Agency","doi-asserted-by":"publisher","award":["08E04AR"],"award-info":[{"award-number":["08E04AR"]}],"id":[{"id":"10.13039\/501100001962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To detect doping with pseudo\u2010endogenous anabolic steroids in sports, a urinary steroid profile with glucuronidated plus unconjugated androgens is used. In addition to analyze androgen glucuronide metabolites, it can be of interest to also include sulfate metabolites in the urinary steroid profile. The combined ratios of epitestosterone sulfate\/epitestosterone glucuronide to the ratios of testosterone sulfate\/testosterone glucuronide ((ES\/EG)\/(TS\/TG)) have previously been investigated as a complementary biomarker for testosterone doping. In this restudy, the aim was to evaluate this biomarker in a larger study sample population. A single dose of 500\u2010mg testosterone enanthate was administered to 54 healthy male volunteers. Urine was collected prior to (Day 0) administration and throughout 15\u2009days and analyzed for the sulfate and glucuronide conjugates of testosterone and epitestosterone. The results show that the combined ratio increased to a larger extent than the traditional T\/E ratio in all subjects. This increase was independent on UGT2B17 gene polymorphism. Moreover, a delayed peak of the combined ratio was observed in ~60% of the participants. The results confirm that complementary analyses of the sulfate metabolites may be a useful approach to detect testosterone doping in men.<\/jats:p>","DOI":"10.1002\/dta.3045","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T07:10:52Z","timestamp":1618643452000},"page":"1576-1579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Re\u2010evaluation of combined ((ES\/EG)\/(TS\/TG)) ratio as a marker of testosterone intake in men"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-9590","authenticated-orcid":false,"given":"Jenny","family":"Schulze","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Pharmacology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Pettersson\u2010Bohlin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Pharmacology Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Pharmacology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u2010Olof","family":"Th\u00f6rngren","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1053-2345","authenticated-orcid":false,"given":"Lena","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Pharmacology Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Pharmacology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2009.11.003"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2885"},{"key":"e_1_2_5_4_1","first-page":"293","volume-title":"Sport: Leistung und Gesundheit, Kongressbd. 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