{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:39:52Z","timestamp":1783978792011,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T00:00:00Z","timestamp":1317772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>A new, simple, rapid, accurate and precise high performance thin layer chromatography (HPTLC) method has been developed for the estimation of ondansetron hydrochloride in bulk and sublingual tablets. The mobile phase composition was chloroform : ethyl acetate : methanol : ammonia (9:5:4:0.1 <jats:italic>v<\/jats:italic>\/<jats:italic>v<\/jats:italic>). Spectrodensitometric analysis of ondansetron was carried out at 254 nm and a symmetrical, well\u2010resolved, well\u2010defined peak was obtained at mean retardation factor (R<jats:sub>f<\/jats:sub>) 0.52 \u00b1 0.02. The calibration plot was linear in the range 200\u20101200 ng\/spot and showed good linear relationship with coefficient of regression, R<jats:sup>2<\/jats:sup> = 0.9952 with respect to peak area. The method was validated according to the guidelines of the International Conference on Harmonization (ICH Q2(R1). The limit of detection and quantitation were 14.83 and 44.92 ng per spot, respectively. The recovery study was carried out by standard addition method and the percentage recovery was found to be 99.34 \u00b1 1.08. Therefore it was concluded that the proposed developed HPTLC method can be applied for identification and quantitative determination of ondansetron in bulk drug and dosage forms. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dta.311","type":"journal-article","created":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T12:14:10Z","timestamp":1317816850000},"page":"122-125","source":"Crossref","is-referenced-by-count":12,"title":["Development of HPTLC method for the estimation of ondansetron hydrochloride in bulk drug and sublingual tablets"],"prefix":"10.1002","volume":"5","author":[{"given":"Ali","family":"Mujtaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan","family":"Kohli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjula","family":"Baboota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199003223221205"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-11-834"},{"issue":"1","key":"e_1_2_6_4_2","first-page":"29","article-title":"Clinical studies with ondansetron in the control of radiation\u2010induced emesis","volume":"25","author":"Priestman T.J.","year":"1989","journal-title":"Eur. 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