{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T17:12:15Z","timestamp":1760375535502,"version":"build-2065373602"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["17DZ2273200","19DZ2292700"],"award-info":[{"award-number":["17DZ2273200","19DZ2292700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002000","81871531"],"award-info":[{"award-number":["82002000","81871531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Drug Testing and Analysis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, overseas anti\u2010obesity drugs including amfepramone have flowed into China through the internet or personal import by travelers. Amfepramone is controlled in China and is not available as a pharmaceutical product. It is obtainable either through the internet or imported by individuals across the border. The abuse of amfepramone is causing serious health problems. A method for the detection and quantification of amfepramone and its metabolite cathinone in human hair was developed and fully validated using liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS). Approximately 10\u00a0mg of hair was weighed and pulverized with extraction solvent (a mixture of methanol: acetonitrile: 2\u2009mM ammonium formate [pH\u00a05.3] [25:29:46, v\/v\/v]). The limit of detection (LOD) and the limit of quantitation (LOQ) were 5 and 10\u00a0pg\/mg, respectively. The method was linear over a concentration range from 10 to 10,000\u2009pg\/mg. The accuracy varied from \u22129.3% to 2.3%, with acceptable intra\u2010 and inter\u2010day precision. The validated method was successfully applied to 17 authentic cases. The amfepramone concentrations ranged from 11.7 to 209\u2009pg\/mg, with a median of 30.2\u00a0pg\/mg, and the hair cathinone concentrations ranged from 11.9 to 507\u2009pg\/mg, with a median of 54.0\u00a0pg\/mg. This is the first report of amfepramone concentrations in human hair from amfepramone users. Cathinone can be incorporated into hair after amfepramone use.<\/jats:p>","DOI":"10.1002\/dta.3149","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T23:22:34Z","timestamp":1629242554000},"page":"101-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detection of amfepramone and its metabolite cathinone in human hair: Application to a uthentic cases of amfepramone use"],"prefix":"10.1002","volume":"14","author":[{"given":"Huan","family":"Yang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang China"},{"name":"Department of Forensic Toxicology Shanghai Key Laboratory of Forensic Medicine  Shanghai 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